Phenotypes for Lrp5 MGI:7467137 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Lrp5^em1Xjz/Lrp5^em1Xjz
Genetic Background	C57BL/6J-Lrp5^em1Xjz

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp5^em1Xjz mutation (0 available); any Lrp5 mutation (81 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

decreased angiogenesis ( J:328283 )

• delayed superior blood vessel growth and defects in vertical blood vessel growth in retina at age P6

• absent secondary and tertiary blood vessels in deeper layers of retina at age P6

• delayed blood vessel growth in deeper layers of retina at age P13

vision/eye

abnormal retina development ( J:328283 )

• delayed superior blood vessel growth and defects in vertical blood vessel growth at age P6

• absent secondary and tertiary blood vessels in deeper layers at age P6

• delayed blood vessel growth in deeper layers at age P13

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
exudative vitreoretinopathy		DOID:0050535	OMIM:PS133780	J:328283

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23