Klf15^tm1Jain
Targeted Allele Detail

Summary

• Symbol: Klf15^tm1Jain
• Name: Kruppel-like transcription factor 15; targeted mutation 1, Mukesh K Jain
• MGI ID: MGI:3054985
• Synonyms: KLF15-LacZ
• Gene: Klf15 Location: Chr6:90439558-90452220 bp, + strand
• Alliance: Klf15^tm1Jain page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92922
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A lacZ-PGK-neo cassette was inserted after the ATG in exon 2 replacing all of exon 2. PCR analysis confirmed the absence of wild-type transcript in homozygous mice. Staining indicated presence of lacZ in adipocytes, cardiomyocytes, skeletal myocytes and smooth muscle cells. (J:92922, J:121109)

Disease models

Expression

In Mice Carrying this Mutation:	6 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Klf15 Mutation: 17 strains or lines available

References

• Original: J:92922 Gray S, et al., The Kruppel-like factor KLF15 regulates the insulin-sensitive glucose transporter GLUT4. J Biol Chem. 2002 Sep 13;277(37):34322-8
• All: 23 reference(s)