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Phenotypes Associated with This Genotype
Genotype
MGI:5823026
Allelic
Composition
Ido1tm1.1Mkks/Ido1tm1.1Mkks
Genetic
Background
B6.Cg-Ido1tm1.1Mkks
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ido1tm1.1Mkks mutation (0 available); any Ido1 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• individual fetuses from mutant dams are smaller than fetuses from control pregnancies, indicating intrauterine growth restriction
• however, the number of fetal-placental units per pregnancy and placental weights are comparable to controls and no differences in the thickness of the labyrinth or spongiotrophoblast layers are seen
• dams exhibit renal pathology and dysfunction at the end of gestation, impaired relaxation of conduit arteries in response to acetylcholine, increased blood pressure during pregnancy, and smaller fetus size

cardiovascular system
• heart rate is not as elevated in mutant pregnant dams as it is in pregnant controls
• pregnant females show mildly elevated blood pressure as the normal pregnancy induced reduction in blood pressure is not seen
• however, overt hypertension during pregnancy is not seen
• conduit arteries (aortae) from pregnant females exhibit impaired relaxation to acetylcholine but normal relaxation response to sodium nitroprusside
• however, second-order branches of mesenteric arteries exhibit normal relaxation responses to both acetylcholine and sodium nitroprusside

homeostasis/metabolism
• about 50% increase in urine protein is seen in urine collected from dams on gestational day 17

muscle
• conduit arteries (aortae) from pregnant females exhibit impaired relaxation to acetylcholine but normal relaxation response to sodium nitroprusside
• however, second-order branches of mesenteric arteries exhibit normal relaxation responses to both acetylcholine and sodium nitroprusside

renal/urinary system
• about 50% increase in urine protein is seen in urine collected from dams on gestational day 17
• pathognomonic glomerular endotheliosis is seen in dams at the end of gestation

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
pre-eclampsia DOID:10591 OMIM:189800
OMIM:609402
OMIM:609403
OMIM:609404
OMIM:614592
J:229059


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory