About   Help   FAQ
Targeted Allele Detail
Symbol: Adamts19tm4b(EUCOMM)Wtsi
Name: ADAM metallopeptidase with thrombospondin type 1 motif 19; targeted mutation 4b, Wellcome Trust Sanger Institute
MGI ID: MGI:6416159
Synonyms: Adamts19KO, Adamts19tm4b
Gene: Adamts19  Location: Chr18:58969739-59187132 bp, + strand  Genetic Position: Chr18, 33.78 cM
Alliance: Adamts19tm4b(EUCOMM)Wtsi page
IMPC: Adamts19 gene page
Mutant Cell Line:  MEPD1003_3_C02
Germline Transmission:  Earliest citation of germline transmission: J:287334
Parent Cell Line:  JM8A3.N1.C2 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: EUCOMM
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion     Vector: L1L2_Bact_P
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 58889767 of Chromosome 18 upstream of the critical exon (exon 3) (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of exon 3 at position 58890644. Exon 3 is thus flanked by loxP sites. A null/knockout allele was created by cre recombinase expression in mice carrying the tm4a allele to remove the neo selection cassette and loxP-flanked critical exon. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:287334)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 54 assay results
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adamts19 Mutation:  39 strains or lines available
Original:  J:287334 Wunnemann F, et al., Loss of ADAMTS19 causes progressive non-syndromic heart valve disease. Nat Genet. 2020 Jan;52(1):40-47
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
MGI 6.22
The Jackson Laboratory