Tg(Kdr-cre)#Brei
Transgene Detail

Summary

• Symbol: Tg(Kdr-cre)#Brei
• Name: transgene insertion, George Breier
• MGI ID: MGI:5428039
• Synonyms: Flk1-Cre
• Transgene: Tg(Kdr-cre)#Brei Location: unknown
• Alliance: Tg(Kdr-cre)#Brei page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Kdr-cre)#Brei expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Kdr

• Mutation details: Sequence encoding cre recombinase was adjoined to Kdr promoter/enhancer sequence to drive expression of cre in the endothelial cells of the embyronic vascular system. The construct consisted of 939 bp of Kdr promoter sequence fused to cre sequence followed by a polyA signal and 2.3 kb of the first intron of Kdr. Cre-mediated recombination of a reporter transgene was observed in the embryonic vasculature at E11.5. Lines 15962 and 15964 were generated. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:88924)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Kdr (species not specified) Summary of all recombinase alleles driven by Kdr.

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:181761 Planas-Paz L, et al., Mechanoinduction of lymph vessel expansion. EMBO J. 2012 Feb 15;31(4):788-804
• All: 9 reference(s)