Phenotypes Associated with This Genotype

Genotype
MGI:5558016

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Scarb1^tm1Kri/Scarb1^tm1Kri
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Apoe^tm1Unc/Apoe^tm1Unc Scarb1^tm1Kri/Scarb1^tm1Kri mice develop occlusive, atherosclerotic coronary artery disease

mortality/aging

premature death ( J:201999 )

• median survival time of approximately 6 weeks

cardiovascular system

atherosclerotic lesions ( J:201999 )

• in the coronary arteries

artery occlusion ( J:201999 )

• coronary artery occlusion

abnormal heart morphology ( J:201999 )

• at 31 days of age small myocardial infarctions are seen and by 43 days of age extensive myocardial infarctions are present

abnormal coronary artery morphology ( J:201999 )

• develop occlusive, atherosclerotic coronary artery disease after 21 days of age

increased heart weight ( J:201999 )

• increase in the heart to body weight ratio in mice over 21 days of age

growth/size/body

increased heart weight ( J:201999 )

• increase in the heart to body weight ratio in mice over 21 days of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
coronary artery disease		DOID:3393	OMIM:300464 OMIM:607339 OMIM:608316 OMIM:608318 OMIM:608320 OMIM:610947 OMIM:611139 OMIM:612030 OMIM:614293	J:201999