Ctnnb1^em1V
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ctnnb1^em1V
• Name: catenin beta 1; endonuclease-mediated mutation 1, ViewSolid Biotech Co., Ltd
• MGI ID: MGI:7466919
• Synonyms: Ctnnb1^floxedexon3
• Gene: Ctnnb1 Location: Chr9:120762466-120789573 bp, + strand Genetic Position: Chr9, 72.19 cM
• Alliance: Ctnnb1^em1V page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted into introns 2 and 3 using sgRNAs and ssODN templates with CRISPR/Cas9 technology. (J:328283)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ctnnb1 Mutation: 49 strains or lines available

References

• Original: J:328283 Zhu X, et al., Catenin alpha 1 mutations cause familial exudative vitreoretinopathy by overactivating Norrin/beta-catenin signaling. J Clin Invest. 2021 Mar 15;131(6)
• All: 1 reference(s)