Ctnna1^tm1Efu
Targeted Allele Detail

Summary

• Symbol: Ctnna1^tm1Efu
• Name: catenin alpha 1; targeted mutation 1, Elaine Fuchs
• MGI ID: MGI:2677796
• Synonyms: alpha-cat fl, floxed alpha-E-catenin
• Gene: Ctnna1 Location: Chr18:35251955-35387829 bp, + strand Genetic Position: Chr18, 18.89 cM
• Alliance: Ctnna1^tm1Efu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67797
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted by homologous recombination that flanked exon 2. An adjacent floxed neomycin selection cassette was removed by Cre-mediated recombination in ES cells prior to the production of chimeric mice. (J:67797)

Disease models

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Ctnna1^tm1Efu

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ctnna1 Mutation: 133 strains or lines available

References

• Original: J:67797 Vasioukhin V, et al., Hyperproliferation and defects in epithelial polarity upon conditional ablation of alpha-catenin in skin. Cell. 2001 Feb 23;104(4):605-17
• All: 30 reference(s)