Analysis Tools
cardiovascular system
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• mice co-injected with a Cre recombinase and a VEGF expressing adenovirus exhibit malformed vessels and increased cerebrovascular density in the brain at the injection site resembling arteriovenous malformations
• co-injection of a Cre recombinase and a VEGF expressing adenovirus induces more cerebrovascular dysplasia in mutants than in similarly injected Engtm2.1Hma homozygotes, however gene deletion efficiency is higher in this mutant and when gene deletion efficiency is the same in both mutants, then this mutant shows fewer dysplastic vessels per gene copy than the Eng mutant
• however, mice co-injected with a Cre recombinase and a VEGF expressing adenovirus exhibit a similar degree of angiogenesis as in wild-type mice injected with the VEGF adenovirus
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nervous system
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• mice co-injected with a Cre recombinase and a VEGF expressing adenovirus exhibit malformed vessels and increased cerebrovascular density in the brain at the injection site resembling arteriovenous malformations
• co-injection of a Cre recombinase and a VEGF expressing adenovirus induces more cerebrovascular dysplasia in mutants than in similarly injected Engtm2.1Hma homozygotes, however gene deletion efficiency is higher in this mutant and when gene deletion efficiency is the same in both mutants, then this mutant shows fewer dysplastic vessels per gene copy than the Eng mutant
• however, mice co-injected with a Cre recombinase and a VEGF expressing adenovirus exhibit a similar degree of angiogenesis as in wild-type mice injected with the VEGF adenovirus
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| arteriovenous malformations of the brain | DOID:0060688 |
OMIM:108010 |
J:196810 | |
