Tnfrsf1b^tm1Imx
Targeted Allele Detail

Summary

• Symbol: Tnfrsf1b^tm1Imx
• Name: tumor necrosis factor receptor superfamily, member 1b; targeted mutation 1, Immunex Research and Development Corporation
• MGI ID: MGI:1860087
• Synonyms: p75-, p75 KO, TNFbeta ko, TNFR2-, TNFRII-, Tnfrsf1^btm1Imx
• Gene: Tnfrsf1b Location: Chr4:144940033-144973440 bp, - strand Genetic Position: Chr4, 78.17 cM
• Alliance: Tnfrsf1b^tm1Imx page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:45147
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin resistance cassette replaced 1kb of sequence encoding amino acids 3 - 26. Lack of gene product was shown functionally. (J:45147)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 5 strains available Cell Lines: 0 lines available
• Carrying any Tnfrsf1b Mutation: 41 strains or lines available

References

• Original: J:45147 Peschon JJ, et al., TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation. J Immunol. 1998 Jan 15;160(2):943-52
• All: 269 reference(s)