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Pten
Gene Detail
Symbol

Name
ID
Pten
phosphatase and tensin homolog
MGI:109583
Synonyms
2310035O07Rik, A130070J02Rik, B430203M17Rik, MMAC1, TEP1
Feature Type
protein coding gene
Genetic Map
Chromosome 19
28.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr19:32757497-32826160 bp, + strand
From VEGA annotation of GRCm38

  68664 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:265  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: bifunctional phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase/dual-specificity protein phosphatase PTEN
Gene Tree: Pten

Human
homologs
Human Homolog PTEN, phosphatase and tensin homolog
NCBI Gene ID 5728
neXtProt AC  NX_P60484
Human Synonyms  10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1
Human Chr (Location)  10q23.3; chr10:87863438-87970345 (+)  GRCh38
Disease Associations  (12) Diseases Associated with Human PTEN
Mutations,
alleles, and
phenotypes
All mutations/alleles(70) : Chemically induced (ENU)(1) Gene trapped(48) Targeted(21)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants die by E9.5 with abnormally patterned enlarged brains and defective placentas. Heterozygotes develop a range of neoplasms. Conditional mutants demonstrate effects on basic processes of proliferation, differentiation and apoptosis.
 
Human Diseases Modeled Using Mouse Pten (20)    Alleles Annotated to Human Diseases(11)    Phenotype Images(13)
Interactions
Pten interacts with 521 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (124 annotations)
Process activation of mitotic anaphase-promoting complex activity, angiogenesis, ...
Component cell projection, cytoplasm, ...
Function anaphase-promoting complex binding, enzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (58 records)
Data Summary: Results (242)    Tissues (187)    Images (46)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 22
RNA in situ 178
Western blot 2
RT-PCR 40
cDNA source data(31)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(35) cDNA(32) Primer pair(3)
Microarray probesets(10)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021203 VEGA Gene Model | MGI Sequence Detail 68664 C57BL/6J ±  kb
transcript OTTMUST00000050229 VEGA | MGI Sequence Detail 8292 Not Applicable 
polypeptide OTTMUSP00000023423 VEGA | MGI Sequence Detail 403 Not Applicable 

For the selected sequences
All sequences(85) RefSeq(5) UniProt(11)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(393 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017361 Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR000340 Dual specificity phosphatase, catalytic domain
InterPro IPR016130 Protein-tyrosine phosphatase, active site
InterPro IPR014020 Tensin phosphatase, C2 domain
Protein Ontology PR:000028746 phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
References
(Earliest) J:39352 Steck PA, et al., Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet. 1997 Apr;15(4):356-62
(Latest) J:214355 Scortegagna M, et al., Genetic inactivation or pharmacological inhibition of Pdk1 delays development and inhibits metastasis of Braf(V600E)::Pten(-/-) melanoma. Oncogene. 2014 Aug 21;33(34):4330-9
All references(728)
Disease annotation references (29)
Other
accession IDs
MGD-MRK-39582, MGI:1917411, MGI:2147557, MGI:2443558

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory