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Pten Gene Detail
Summary
  • Symbol
    Pten
  • Name
    phosphatase and tensin homolog
  • Synonyms
    2310035O07Rik, A130070J02Rik, B430203M17Rik, MMAC1, TEP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:109583
    NCBI Gene: 19211
  • Gene Overview
    MyGene.info: PTEN
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:32757577-32826160 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 28.14 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    393 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109583
protein coding gene Chr19:32757497-32826160 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025043
protein coding gene Chr19:31414034-31488250 (+)
A/J MGP_AJ_G0025020
protein coding gene Chr19:29849452-29917301 (+)
AKR/J MGP_AKRJ_G0024988
protein coding gene Chr19:30893051-30962664 (+)
BALB/cJ MGP_BALBcJ_G0025019
protein coding gene Chr19:29906024-29977207 (+)
C3H/HeJ MGP_C3HHeJ_G0024775
protein coding gene Chr19:30890775-30961909 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025460
protein coding gene Chr19:32300582-32375501 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022879
protein coding gene Chr19:29762175-29830608 (+)
CAST/EiJ MGP_CASTEiJ_G0024246
protein coding gene Chr19:30796934-30868360 (+)
CBA/J MGP_CBAJ_G0024753
protein coding gene Chr19:33790058-33868433 (+)
DBA/2J MGP_DBA2J_G0024885
protein coding gene Chr19:29768957-29837498 (+)
FVB/NJ MGP_FVBNJ_G0024847
protein coding gene Chr19:29598497-29664332 (+)
LP/J MGP_LPJ_G0024970
protein coding gene Chr19:31419114-31491656 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024874
protein coding gene Chr19:33662819-33742669 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025515
protein coding gene Chr19:30957224-31030255 (+)
PWK/PhJ MGP_PWKPhJ_G0023994
protein coding gene Chr19:29474085-29543445 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023798
protein coding gene Chr19:30272426-30342248 (+)
WSB/EiJ MGP_WSBEiJ_G0024312
protein coding gene Chr19:30981845-31051445 (+)



Homology
more
  • Human Ortholog
    PTEN, phosphatase and tensin homolog
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PTEN, phosphatase and tensin homolog
    Orthology source: HomoloGene, HGNC
  • Synonyms
    10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, PTENbeta, TEP1
  • Links
    NCBI Gene ID: 5728
    neXtProt AC: NX_P60484
    UniProt: P60484

  • Chr Location
    10q23.31; chr10:87863438-87971930 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    14 with Pten mouse models; 6 with human PTEN associations

Human Disease Mouse Models
      
IDs
View 12 models
IDs
View 2 models
IDs
View 17 models
      
IDs
View 1 model
IDs
View 3 models
IDs
View 3 models
IDs
View 1 model
IDs
View 3 models
IDs
View 2 models
IDs
View 3 models
IDs
View 3 models
IDs
View 1 model
IDs
View 1 model
IDs
View 3 models
      
IDs
IDs
View 5 models
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    13 with disease annotations
  • References
    75 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    526 phenotypes from 20 alleles in 78 genetic backgrounds
    279 phenotypes from multigenic genotypes
    27 images
    946 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutants die by E9.5 with abnormally patterned enlarged brains and defective placentas. Heterozygotes develop a range of neoplasms. Conditional mutants demonstrate effects on basic processes of proliferation, differentiation and apoptosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19211 NCBI Gene Model | MGI Sequence Detail 68584 C57BL/6J ±  kb
    transcript NM_008960 RefSeq | MGI Sequence Detail 8229 C57BL/6  
    polypeptide O08586 UniProt | EBI | MGI Sequence Detail 403 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000028746 phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
    • EC
    • InterPro Domains
      IPR017361 Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN
      IPR000340 Dual specificity phosphatase, catalytic domain
      IPR016130 Protein-tyrosine phosphatase, active site
      IPR003595 Protein-tyrosine phosphatase, catalytic
      IPR029021 Protein-tyrosine phosphatase-like
      IPR014020 Tensin phosphatase, C2 domain
      IPR029023 Tensin-type phosphatase domain
    Molecular
    Reagents
    less
    • All nucleic 38
      cDNA 33
      Primer pair 4
      Other 1

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGD-MRK-39582, MGI:1917411, MGI:2147557, MGI:2443558
    References
    more
    • Summaries
      All 1208
      Developmental Gene Expression 79
      Diseases 75
      Gene Ontology 40
      Phenotypes 946
    • Earliest
      J:39352 Steck PA, et al., Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet. 1997 Apr;15(4):356-62
    • Latest
      J:266099 Sizemore GM, et al., Stromal PTEN determines mammary epithelial response to radiotherapy. Nat Commun. 2018 Jul 17;9(1):2783

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory