Pten
Gene Detail

Symbol Name ID

Pten phosphatase and tensin homolog MGI:109583

Synonyms

2310035O07Rik, A130070J02Rik, B430203M17Rik, MMAC1, TEP1

Feature Type

protein coding gene

Genetic Map

Chromosome 19

28.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)

Sequence Map

Chr19:32757497-32826160 bp, + strand From VEGA annotation of GRCm38   68664 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:265  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: bifunctional phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase/dual-specificity protein phosphatase PTEN
Gene Tree: Pten

Human homologs

Human Homolog		PTEN, phosphatase and tensin homolog
NCBI Gene ID		5728
neXtProt AC		NX_P60484
Human Synonyms		10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1
Human Chr (Location)		10q23.3; chr10:89623195-89728532 (+)  GRCh37.p10
Disease Associations		(12) Diseases Associated with Human PTEN

Alleles and phenotypes

All alleles(68) : Targeted(19) Gene trapped(48) Chemically induced(1)
 

Homozygous null mutants die by E9.5 with abnormally patterned enlarged brains and defective placentas. Heterozygotes develop a range of neoplasms. Conditional mutants demonstrate effects on basic processes of proliferation, differentiation and apoptosis.

 
Human Diseases Modeled Using Mouse Pten (16)    Alleles Annotated to Human Diseases(11)    Phenotype Images(5)

Gene Ontology (GO) classifications

All GO classifications: (121 annotations)

Process	activation of mitotic anaphase-promoting complex activity, angiogenesis, ...
Component	cell projection, cytoplasm, ...
Function	anaphase-promoting complex binding, enzyme binding, ...

External Resources: FuncBase

Expression

Literature Summary: (53 records)
Data Summary: Results (242)    Tissues (187)    Images (46)
Theiler Stages: 2, 3, 10, 14, 15, 16, 17, 18, 19, 21, 22, 23, 24, 25, 28

Assay Type	Results
Immunohistochemistry	22
RNA in situ	178
Western blot	2
RT-PCR	40

cDNA source data(31)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(35) cDNA(32) Primer pair(3)
Microarray probesets(10)

Other database links

VEGA Gene Model	OTTMUSG00000021203 (Evidence)
Ensembl Gene Model	ENSMUSG00000013663 (Evidence)
Entrez Gene	19211 (Evidence)
DFCI	TC1577438, TC1586330, TC1602136, TC1608718, TC1614526, TC1622089, TC1647285, TC1675135
DoTS	DT.101162561, DT.101391857, DT.101724232, DT.110880294, DT.493342, DT.91315431, DT.91320841, DT.91597685, DT.97370271, DT.97402046
NIA Mouse Gene Index	U019374, U021628, U044918, U342000, U370734
EC	3.1.3.16, 3.1.3.48, 3.1.3.67
Consensus CDS Project	CCDS29753.1
International Mouse Knockout Project Status	Pten

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021203	VEGA Gene Model | MGI Sequence Detail	68664	C57BL/6J
transcript	OTTMUST00000050229	VEGA | MGI Sequence Detail	8292	Not Applicable
polypeptide	OTTMUSP00000023423	VEGA | MGI Sequence Detail	403	Not Applicable

All sequences(76) RefSeq(3) UniProt(5)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(361 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017361	Bifunctional phosphatidylinositol trisphosphate phosphatase/dual-specificity phosphatase PTEN
InterPro	IPR008973	C2 calcium/lipid-binding domain, CaLB
InterPro	IPR000340	Dual specificity phosphatase, catalytic domain
InterPro	IPR014019	Phosphatase tensin type
InterPro	IPR016130	Protein-tyrosine phosphatase, active site
InterPro	IPR014020	Tensin phosphatase, C2 domain
Protein Ontology	PR:000028746	phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

References

(Earliest) J:39352 Steck PA, et al., Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet. 1997 Apr;15(4):356-62
(Latest) J:195200 Wang ZA, et al., Lineage analysis of basal epithelial cells reveals their unexpected plasticity and supports a cell-of-origin model for prostate cancer heterogeneity. Nat Cell Biol. 2013 Mar;15(3):274-83
All references(580)

Other accession IDs

MGD-MRK-39582, MGI:1917411, MGI:2147557, MGI:2443558