About   Help   FAQ
Pten
Gene Detail
Symbol

Name
ID
Pten
phosphatase and tensin homolog
MGI:109583
Synonyms
2310035O07Rik, A130070J02Rik, B430203M17Rik, MMAC1, TEP1
Feature Type
protein coding gene
Genetic Map
Chromosome 19
28.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr19:32757497-32826160 bp, + strand
From VEGA annotation of GRCm38

  68664 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:265  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PTEN
Protein SuperFamily: bifunctional phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase/dual-specificity protein phosphatase PTEN
Gene Tree: Pten

Human
homologs
PTEN, phosphatase and tensin homolog
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5728
neXtProt AC: NX_P60484

Human Synonyms: 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1

Human Chr (Location): 10q23.3; chr10:87863438-87971930 (+)  GRCh38.p2

Disease Associations: (12) Diseases Associated with Human PTEN

Mutations,
alleles, and
phenotypes
All mutations/alleles(72) : Chemically induced (ENU)(1) Gene trapped(48) Targeted(23)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants die by E9.5 with abnormally patterned enlarged brains and defective placentas. Heterozygotes develop a range of neoplasms. Conditional mutants demonstrate effects on basic processes of proliferation, differentiation and apoptosis.
 
Human Diseases Modeled in Mice Using Pten (13)    Mutations Annotated to Human Diseases (12)    Phenotype Images(13)
Interactions
Pten interacts with 520 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (133 annotations)
Process activation of APC-Cdc20 complex activity, angiogenesis, ...
Component apical plasma membrane, cell projection, ...
Function anaphase-promoting complex binding, enzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (61 records)
Data Summary: Results (290)    Tissues (212)    Images (57)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 50
RNA in situ 178
Northern blot 4
Western blot 16
RT-PCR 42
cDNA source data(31)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA PTEN ; Xenbase pten ; ZFIN ptena, ptenb    NEW 
Molecular
reagents
All nucleic(37) cDNA(32) Primer pair(4) Other(1)
Microarray probesets(10)
Other database
links
VEGA Gene Model OTTMUSG00000021203 (Evidence)
Ensembl Gene Model ENSMUSG00000013663 (Evidence)
Entrez Gene 19211 (Evidence)
DFCI TC1675135, TC1622089, TC1647285, TC1614526, TC1602136, TC1586330, TC1577438, TC1608718
DoTS DT.101724232, DT.101391857, DT.101162561, DT.91315431, DT.493342, DT.110880294, DT.91320841, DT.97402046, DT.97370271, DT.91597685
NIA Mouse Gene Index U370734, U342000, U044918, U021628, U019374
EC 3.1.3.67, 3.1.3.48, 3.1.3.16
Consensus CDS Project CCDS29753.1
International Mouse Phenotyping Consortium Status Pten
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021203 VEGA Gene Model | MGI Sequence Detail 68664 C57BL/6J ±  kb
transcript OTTMUST00000050229 VEGA | MGI Sequence Detail 8292 Not Applicable 
polypeptide OTTMUSP00000023423 VEGA | MGI Sequence Detail 403 Not Applicable 

For the selected sequences
All sequences(80) RefSeq(5) UniProt(6)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(393 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017361 Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR000340 Dual specificity phosphatase, catalytic domain
InterPro IPR016130 Protein-tyrosine phosphatase, active site
InterPro IPR014020 Tensin phosphatase, C2 domain
Protein Ontology PR:000028746 phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
References
(Earliest) J:39352 Steck PA, et al., Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet. 1997 Apr;15(4):356-62
(Latest) J:221670 Geoffroy CG, et al., Effects of PTEN and Nogo Codeletion on Corticospinal Axon Sprouting and Regeneration in Mice. J Neurosci. 2015 Apr 22;35(16):6413-28
All references(782)
Disease annotation references (36)
Other
accession IDs
MGD-MRK-39582, MGI:1917411, MGI:2147557, MGI:2443558

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/28/2015
MGI 5.22
The Jackson Laboratory