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Gene Detail
phosphatase and tensin homolog
Synonyms 2310035O07Rik, A130070J02Rik, B430203M17Rik, MMAC1, TEP1
Feature Type protein coding gene
Genetic Map
Chromosome 19
28.14 cM
Detailed Genetic Map ± 1 cM

Mapping data(11)
Sequence Map
Chr19:32757497-32826160 bp, + strand
From VEGA annotation of GRCm38

  68664 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:265  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: bifunctional phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase/dual-specificity protein phosphatase PTEN
Gene Tree: Pten

Human Homolog PTEN, phosphatase and tensin homolog
NCBI Gene ID 5728
neXtProt AC  NX_P60484
Human Synonyms  10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1
Human Chr (Location)  10q23.3; chr10:87863438-87970345 (+)  GRCh38
Disease Associations  (12) Diseases Associated with Human PTEN
alleles, and
All mutations/alleles(69) : Chemically induced (ENU)(1) Gene trapped(48) Targeted(20)
Incidental mutations (data from Mutagenetix , APF )
Homozygous null mutants die by E9.5 with abnormally patterned enlarged brains and defective placentas. Heterozygotes develop a range of neoplasms. Conditional mutants demonstrate effects on basic processes of proliferation, differentiation and apoptosis.
Human Diseases Modeled Using Mouse Pten (20)    Alleles Annotated to Human Diseases(11)    Phenotype Images(8)
Pten interacts with 521 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
All GO classifications: (123 annotations)
Process activation of mitotic anaphase-promoting complex activity, angiogenesis, ...
Component cell projection, cytoplasm, ...
Function anaphase-promoting complex binding, enzyme binding, ...
External Resources: FuncBase
Literature Summary: (57 records)
Data Summary: Results (242)    Tissues (187)    Images (46)
Theiler Stages: 2, 3, 10, 14, 15, 16, 17, 18, 19, 21, 22, 23, 24, 25, 28
Assay TypeResults
Immunohistochemistry 22
RNA in situ 178
Western blot 2
cDNA source data(31)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
All nucleic(35) cDNA(32) Primer pair(3)
Microarray probesets(10)
Other database
VEGA Gene ModelOTTMUSG00000021203 (Evidence)
Ensembl Gene ModelENSMUSG00000013663 (Evidence)
Entrez Gene19211 (Evidence)
DFCITC1577438, TC1586330, TC1602136, TC1608718, TC1614526, TC1622089, TC1647285, TC1675135
DoTSDT.101162561, DT.101391857, DT.101724232, DT.110880294, DT.493342, DT.91315431, DT.91320841, DT.91597685, DT.97370271, DT.97402046
NIA Mouse Gene IndexU019374, U021628, U044918, U342000, U370734
Consensus CDS ProjectCCDS29753.1
International Mouse Knockout Project StatusPten
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021203 VEGA Gene Model | MGI Sequence Detail 68664 C57BL/6J ±  kb
transcript OTTMUST00000050229 VEGA | MGI Sequence Detail 8292 Not Applicable 
polypeptide OTTMUSP00000023423 VEGA | MGI Sequence Detail 403 Not Applicable 

For the selected sequences
All sequences(80) RefSeq(5) UniProt(6)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(393 from dbSNP Build 137)
InterPro IPR017361 Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR000340 Dual specificity phosphatase, catalytic domain
InterPro IPR016130 Protein-tyrosine phosphatase, active site
InterPro IPR014020 Tensin phosphatase, C2 domain
Protein Ontology PR:000028746 phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
References (Earliest) J:39352 Steck PA, et al., Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet. 1997 Apr;15(4):356-62
(Latest) J:212591 Ai J, et al., Concomitant loss of EAF2/U19 and Pten synergistically promotes prostate carcinogenesis in the mouse model. Oncogene. 2014 May 1;33(18):2286-94
All references(713)
Disease annotation references (29)
accession IDs
MGD-MRK-39582, MGI:1917411, MGI:2147557, MGI:2443558

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory