Phenotypes Associated with This Genotype

Genotype
MGI:5442747

• Allelic Composition: Pten^tm1Rps/Pten⁺; Tg(Wnt1)1Hev/0
• Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary gland ductal carcinoma incidence ( J:67497 )

• 50% of females develop mammary ductal carcinoma by 3.5 months of age, earlier than single Tg(Wnt1)1Hev hemizygotes, and all females show tumors by 5 months of age

• 2 of 22 tumors in males are mammary in origin

increased metastatic potential ( J:67497 )

• mutants occasionally show pulmonary metastasis

increased adenocarcinoma incidence ( J:67497 )

• tumors are adenocarcinomas with cribiform, cystic and focal papillary growth patterns

• 50% of males develop tumors by 5.5 months and all males develop tumors within 10 months

• 50% of females develop tumors by 3.5 months of age and all females have tumors within 5 months of age

• 6 of 22 tumors in males are bilateral or unilateral muzzle tumors of epithelial origin

• 7 or 11 tumors show loss of Pten heterozygosity

• most mutants (38 of 49) develop only one palpable tumor

increased salivary adenocarcinoma incidence ( J:67497 )

♂ • 14 of 22 tumors in males arise in the salivary tissue

increased mammary adenocarcinoma incidence ( J:67497 )

endocrine/exocrine glands

increased salivary adenocarcinoma incidence ( J:67497 )

♂ • 14 of 22 tumors in males arise in the salivary tissue

increased mammary adenocarcinoma incidence ( J:67497 )

increased mammary gland ductal carcinoma incidence ( J:67497 )

• 50% of females develop mammary ductal carcinoma by 3.5 months of age, earlier than single Tg(Wnt1)1Hev hemizygotes, and all females show tumors by 5 months of age

• 2 of 22 tumors in males are mammary in origin

integument

increased mammary adenocarcinoma incidence ( J:67497 )

increased mammary gland ductal carcinoma incidence ( J:67497 )

• 50% of females develop mammary ductal carcinoma by 3.5 months of age, earlier than single Tg(Wnt1)1Hev hemizygotes, and all females show tumors by 5 months of age

• 2 of 22 tumors in males are mammary in origin

digestive/alimentary system

increased salivary adenocarcinoma incidence ( J:67497 )

♂ • 14 of 22 tumors in males arise in the salivary tissue

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:67497