Col1a1tm2(CAG-EGFR*)Char
Targeted Allele Detail
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Symbol: |
Col1a1tm2(CAG-EGFR*)Char |
Name: |
collagen, type I, alpha 1; targeted mutation 2, Al Charest |
MGI ID: |
MGI:3837826 |
Synonyms: |
Col1alpha1-EGFRvIII |
Gene: |
Col1a1 Location: Chr11:94827050-94843868 bp, + strand Genetic Position: Chr11, 59.01 cM, cytoband D
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Alliance: |
Col1a1tm2(CAG-EGFR*)Char page
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Allele Type: |
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Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence, No functional change) |
Mutation: |
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Insertion
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Col1a1tm2(CAG-EGFR*)Char expresses
1 gene
Knock-in expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
EGFR (1956) |
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Mutation details: A CAG promoter was used to drive expression the oncogenic variant vIII of human EGFR with an intervening floxed STOP cassette inserted into the 3' untranslated region. The mutant form contains an in-frame deletion of exons 2 through 7 and codes for a ligand independent receptor.
(J:146494)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Col1a1 Mutation: |
165 strains or lines available
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Original: |
J:146494 Zhu H, et al., Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis. Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2712-6 |
All: |
7 reference(s) |
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