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Phenotypes Associated with This Genotype
Genotype
MGI:4944273
Allelic
Composition
Errfi1tm1Jwj/Errfi1tm1Jwj
Pgrtm2(cre)Lyd/Pgr+
Ptentm1Hwu/Ptentm1Hwu
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Errfi1tm1Jwj mutation (0 available); any Errfi1 mutation (13 available)
Pgrtm2(cre)Lyd mutation (0 available); any Pgr mutation (50 available)
Ptentm1Hwu mutation (16 available); any Pten mutation (76 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• survival time of double mutants is shorter than either single mutant, with mice dying by 16 weeks of age

reproductive system
• development of endometrial cancer is accelerated compared to either single mutant
• decrease in the number of apoptotic cells in the endothelium epithelium compared to single Pten mutants
• proliferation is increased in the endothelium epithelium
• mutants exhibit endometrial hyperplasia at 2 weeks of age and develop endometrial adenocarcinoma at 4 weeks of age
• however, myometrial hyperplasia is not observed in the uteri of mutants
• increase in uterine weight at 2 weeks of age, with weight at 4 weeks greater than in single Pten mutants

neoplasm
• mutants exhibit distant metastases into the ovary, diaphragmatic skeletal muscle, lymph node, colon and pancreas
• development of endometrial cancer is accelerated compared to either single mutant

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
endometrial cancer DOID:1380 OMIM:608089
J:162027


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/30/2023
MGI 6.22
The Jackson Laboratory