Pgrtm2(cre)Lyd
Targeted Allele Detail
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Symbol: |
Pgrtm2(cre)Lyd |
Name: |
progesterone receptor; targeted mutation 2, John P Lydon |
MGI ID: |
MGI:3576366 |
Synonyms: |
Pgrcre, PRCre, PR-Cre |
Gene: |
Pgr Location: Chr9:8899834-8968612 bp, + strand Genetic Position: Chr9, 2.46 cM
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Alliance: |
Pgrtm2(cre)Lyd page
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Allele Type: |
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Targeted (Recombinase) |
Mutation: |
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Insertion
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Pgrtm2(cre)Lyd expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Pgr (MGI:97567) |
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Mutation details: Cre recombinase cDNA was inserted into exon 1. An untranslated region was created immediately 5' of the cDNA by mutating the ATG codon for the B isoform to prevent an in-frame fusion from the N-terminal of the cre cDNA to the remaining 120 amino acids at the N-terminal end of the endogenous gene. A loxP-flanked neo was inserted 3' of the cre insertion. RNase protection analysis demonstrated that cre transcription was restricted to progestin target tissues, including the uterus, mammary gland and oviduct/ovary.
(J:97321)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Pgr
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Pgr Mutation: |
50 strains or lines available
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Original: |
J:97321 Soyal SM, et al., Cre-mediated recombination in cell lineages that express the progesterone receptor. Genesis. 2005 Feb;41(2):58-66 |
All: |
189 reference(s) |
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