About   Help   FAQ
Targeted Allele Detail
Symbol: Pgrtm2(cre)Lyd
Name: progesterone receptor; targeted mutation 2, John P Lydon
MGI ID: MGI:3576366
Synonyms: Pgrcre, PRCre, PR-Cre
Gene: Pgr  Location: Chr9:8899834-8968612 bp, + strand  Genetic Position: Chr9, 2.46 cM
Alliance: Pgrtm2(cre)Lyd page
Germline Transmission:  Earliest citation of germline transmission: J:97321
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
Pgrtm2(cre)Lyd expression driven by 1 gene
Mutation detailsCre recombinase cDNA was inserted into exon 1. An untranslated region was created immediately 5' of the cDNA by mutating the ATG codon for the B isoform to prevent an in-frame fusion from the N-terminal of the cre cDNA to the remaining 120 amino acids at the N-terminal end of the endogenous gene. A loxP-flanked neo was inserted 3' of the cre insertion. RNase protection analysis demonstrated that cre transcription was restricted to progestin target tissues, including the uterus, mammary gland and oviduct/ovary. (J:97321)
 Tissue activity of this recombinase allele
Driver: Pgr (mouse)
Summary of all recombinase alleles driven by Pgr.

View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 25 assay results
Tumor Data
List all tumor models in MMHCdb carrying Pgrtm2(cre)Lyd
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pgr Mutation:  50 strains or lines available
Original:  J:97321 Soyal SM, et al., Cre-mediated recombination in cell lineages that express the progesterone receptor. Genesis. 2005 Feb;41(2):58-66
All:  189 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Copyright, and Privacy Statement
Send questions and comments to User Support.
last database update
MGI 6.22
The Jackson Laboratory