Pgr^tm2(cre)Lyd
Targeted Allele Detail

Summary

• Symbol: Pgr^tm2(cre)Lyd
• Name: progesterone receptor; targeted mutation 2, John P Lydon
• MGI ID: MGI:3576366
• Synonyms: Pgr^cre, PR^Cre, PR-Cre
• Gene: Pgr Location: Chr9:8899834-8968612 bp, + strand Genetic Position: Chr9, 2.46 cM
• Alliance: Pgr^tm2(cre)Lyd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97321
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Pgr^tm2(cre)Lyd expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Pgr (MGI:97567)

• Mutation details: Cre recombinase cDNA was inserted into exon 1. An untranslated region was created immediately 5' of the cDNA by mutating the ATG codon for the B isoform to prevent an in-frame fusion from the N-terminal of the cre cDNA to the remaining 120 amino acids at the N-terminal end of the endogenous gene. A loxP-flanked neo was inserted 3' of the cre insertion. RNase protection analysis demonstrated that cre transcription was restricted to progestin target tissues, including the uterus, mammary gland and oviduct/ovary. (J:97321)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Pgr (mouse) Summary of all recombinase alleles driven by Pgr. Comparative matrix view of recombinase activities Alliance mouse Pgr gene page

Disease models

Expression

In Mice Carrying this Mutation:

25 assay results

Tumor Data

List all tumor models in MMHCdb carrying Pgr^tm2(cre)Lyd

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pgr Mutation: 50 strains or lines available

References

• Original: J:97321 Soyal SM, et al., Cre-mediated recombination in cell lineages that express the progesterone receptor. Genesis. 2005 Feb;41(2):58-66
• All: 189 reference(s)