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Symbol Name ID |
Pten
phosphatase and tensin homolog MGI:109583 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Decreased circulating antibody level |
| Disease(s) Associated with PTEN | |
| Bannayan-Riley-Ruvalcaba syndrome | |
| macrocephaly-autism syndrome |
| Mouse Phenotypes | cellular phenotype |
increased adipocyte glucose uptake |
increased myocardial fiber mitochondrial DNA content |
abnormal oocyte morphology |
abnormal intestinal goblet cell morphology |
abnormal mitochondrial morphology |
disorganized mitochondrial cristae |
abnormal cell physiology |
abnormal mitophagy |
decreased cellular sensitivity to oxidative stress |
increased B cell apoptosis |
decreased granulosa cell apoptosis |
increased hepatocyte apoptosis |
abnormal Bergmann glial cell differentiation |
abnormal neuron differentiation |
impaired luteal cell differentiation |
abnormal macrophage chemotaxis |
abnormal neuronal migration |
increased B cell proliferation |
increased granulosa cell proliferation |
increased lung endothelial cell proliferation |
increased mesenchymal cell proliferation involved in lung development |
abnormal neuronal precursor proliferation |
increased pancreatic beta cell proliferation |
abnormal small intestinal crypt cell proliferation |
decreased cell proliferation |
increased cell proliferation |
increased hepatocyte proliferation |
abnormal cellular cholesterol metabolism |
abnormal cellular respiration |
oxidative stress |
abnormal endocytosis |
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| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||
| Ptentm1.1Yxy/Ptentm1.1Yxy | * | ||||||||||||||||||||||||||||||||
| Ptentm1Engc/Ptentm1Engc | |||||||||||||||||||||||||||||||||
| Ptentm1Engc/Pten+ | |||||||||||||||||||||||||||||||||
| Tg(Pten)1Srn/0 | |||||||||||||||||||||||||||||||||
| Ptentm1Hwu/Ptentm1Hwu Tg(Gfap-cre)77.6Mvs/0 (conditional) |
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| Ptentm1Hwu/Ptentm1Hwu Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ (conditional) |
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| Cd19tm1(cre)Cgn/Cd19+ Ptentm1Hwu/Ptentm1Hwu (conditional) |
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| Ptentm1Hwu/Ptentm1Hwu Tg(GFAP-cre)25Mes/0 (conditional) |
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| Ptentm1Hwu/Ptentm1Hwu Lyz2tm1(cre)Ifo/Lyz2+ (conditional) |
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| Ptentm1Hwu/Ptentm1Hwu Tg(Ins2-cre)25Mgn/0 (conditional) |
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| Ptentm1Hwu/Ptentm1Hwu Tg(Gdf9-icre)5092Coo/0 (conditional) |
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| Ptentm1Hwu/Ptentm1Hwu Tg(CYP19A1-cre)1Jri/0 (conditional) |
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| Ptentm1Hwu/Ptentm1Hwu Tg(Vil1-cre)997Gum/0 (conditional) |
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| Ptentm1Hwu/Ptentm1Hwu Tg(Nkx2-1-cre)2Sand/0 (conditional) |
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| Ptentm1Mro/Ptentm1Mro Tg(En2-cre)22Alj/0 (conditional) |
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| Ptentm2Mak/Ptentm2Mak Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ (conditional) |
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| Ptentm2Mak/Ptentm2Mak Tg(SFTPC-rtTA)5Jaw/0 Tg(tetO-cre)1Jaw/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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