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Phenotypes Associated with This Genotype
Genotype
MGI:5790977
Allelic
Composition		 Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor
Ptentm1Mro/Ptentm1Mro
Trp53tm1Brn/Trp53tm1Brn
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (10 available); any Gt(ROSA)26Sor mutation (1046 available)
Ptentm1Mro mutation (1 available); any Pten mutation (86 available)
Trp53tm1Brn mutation (20 available); any Trp53 mutation (238 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased glioma incidence ( J:229481 )
• mice injected with an adenovirus expressing cre recombinase (Ad-Cre) into the left ventricle exhibit a 33.3% incidence of glioma
increased astrocytoma incidence ( J:229481 )
• in left ventricle Ad-cre injected mice
increased oligodendroglioma incidence ( J:229481 )
• in left ventricle Ad-cre injected mice

nervous system
increased glioma incidence ( J:229481 )
• mice injected with an adenovirus expressing cre recombinase (Ad-Cre) into the left ventricle exhibit a 33.3% incidence of glioma
increased astrocytoma incidence ( J:229481 )
• in left ventricle Ad-cre injected mice
increased oligodendroglioma incidence ( J:229481 )
• in left ventricle Ad-cre injected mice

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
high grade glioma DOID:3070 OMIM:PS137800
 J:229481

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory