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Phenotypes Associated with This Genotype
Genotype
MGI:5517709
Allelic
Composition
Ptentm1Hwu/Pten+
Tg(Nkx2-1-cre)2Sand/0
Genetic
Background
B6.Cg-Ptentm1Hwu Tg(Nkx2-1-cre)2Sand
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Hwu mutation (16 available); any Pten mutation (83 available)
Tg(Nkx2-1-cre)2Sand mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• altered thyroid structure with normal areas that include colloid-filled follicles and normal areas with focal hyperplasia, polynuclear cells, small nonencapsulated areas of hypercellularity with solid and/or mircofollicular patterns and internal hemorrhage
• 100% of mutants develop differentiated follicular tumors of the thyroid after about 2 years of age

homeostasis/metabolism
• P14 mutants show a mild decrease of T4 but normal TSH

neoplasm
• 100% of mutants develop differentiated follicular tumors of the thyroid after about 2 years of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
thyroid gland follicular carcinoma DOID:3962 OMIM:188470
J:197590


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/02/2024
MGI 6.13
The Jackson Laboratory