Phenotypes Associated with This Genotype

Genotype
MGI:5790976

• Allelic Composition: Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor^tm1Sor; Pten^tm1Mro/Pten^tm1Mro; Slc1a3^{tm1(cre/ERT2)Mgoe}/Slc1a3⁺; Trp53^tm1Brn/Trp53^tm1Brn
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJaeSor

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased glioma incidence ( J:229481 )

• 3 of 16 mice injected with endoxifen develop glial tumors with lesions of different sizes and varying extents of infiltration

• small neoplastic lesions in endoxifen-induced mice arise from beneath the SVZ and extend into the striatum and dorsally into the corpus callosum

• larger tumors of endoxifen-induced mice show expansion into and a diffuse infiltration of the entire caudate nucleus

• some tumors contain areas of necrosis and occasional microvascular proliferations similar to those in malignant gliomas

increased astrocytoma incidence ( J:229481 )

• endoxifen-induced tumors show glial morphology with features typical of astrocytomas and oligodendrogliomas

increased oligodendroglioma incidence ( J:229481 )

• endoxifen-induced tumors show glial morphology with features typical of astrocytomas and oligodendrogliomas

nervous system

increased glioma incidence ( J:229481 )

• 3 of 16 mice injected with endoxifen develop glial tumors with lesions of different sizes and varying extents of infiltration

• small neoplastic lesions in endoxifen-induced mice arise from beneath the SVZ and extend into the striatum and dorsally into the corpus callosum

• larger tumors of endoxifen-induced mice show expansion into and a diffuse infiltration of the entire caudate nucleus

• some tumors contain areas of necrosis and occasional microvascular proliferations similar to those in malignant gliomas

increased astrocytoma incidence ( J:229481 )

• endoxifen-induced tumors show glial morphology with features typical of astrocytomas and oligodendrogliomas

increased oligodendroglioma incidence ( J:229481 )

• endoxifen-induced tumors show glial morphology with features typical of astrocytomas and oligodendrogliomas

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
high grade glioma		DOID:3070	OMIM:PS137800	J:229481