Phenotypes Associated with This Genotype

Genotype
MGI:4839508

• Allelic Composition: Erbb2^{tm8(Erbb2)Mul}/Erbb2⁺; Pten^tm1Hwu/Pten⁺; Tg(MMTV-cre)7Mul/0
• Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:133305 )

• mammary tumor onset is accelerated in virgin females compared with either single Pten or single Erbb2 mutants, with tumor latencies of 6.5 compared with 15.3 months

• tumor progression is associated with loss of heterozygosity at the Pten locus in 50% of mutant mammary tumors

• tumors are similar to basal-like subtype of human breast cancer

increased metastatic potential ( J:133305 )

• 35% incidence of lung metastases compared with 5% in single Erbb2 mutants

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:133305 )

• mammary tumor onset is accelerated in virgin females compared with either single Pten or single Erbb2 mutants, with tumor latencies of 6.5 compared with 15.3 months

• tumor progression is associated with loss of heterozygosity at the Pten locus in 50% of mutant mammary tumors

• tumors are similar to basal-like subtype of human breast cancer

integument

increased mammary gland tumor incidence ( J:133305 )

• mammary tumor onset is accelerated in virgin females compared with either single Pten or single Erbb2 mutants, with tumor latencies of 6.5 compared with 15.3 months

• tumor progression is associated with loss of heterozygosity at the Pten locus in 50% of mutant mammary tumors

• tumors are similar to basal-like subtype of human breast cancer

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:133305