Phenotypes Associated with This Genotype

Genotype
MGI:4442335

• Allelic Composition: Pten^tm2.1Gle/Pten⁺
• Genetic Background: involves: 129S6/SvEvTac * Black Swiss * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:158751 )

• mammary intraepithelial neoplasia in females

• females develop large palpable tumors with adenosquamous morphology and a prominent stromal component

• increased coincidence in females of mammary tumor and lymph node neoplasms

• a few males develop high grade mammary intraepithelial neoplasia

increased mammary adenoacanthoma incidence ( J:158751 )

• adenosquamous carcinoma

increased adrenal gland tumor incidence ( J:158751 )

• 70.7% of 9 month old mice develop proliferative lesions of the adrenal gland

increased prostate gland tumor incidence ( J:158751 )

♂ • 86.4% of 9 month old mice develop proliferative lesions of the prostate

increased thyroid tumor incidence ( J:158751 )

• 81.6% of 9 month old mice develop proliferative lesions of the thyroid

increased lymphoma incidence ( J:158751 )

• 55.8% of 9 month old mice develop proliferative lesions of the lymph node

• increased coincidence of lymph node neoplasms and mammary tumors in females

increased T cell derived lymphoma incidence ( J:158751 )

• 59.5% of 9 month old mice develop proliferative lesions of the thymus

endocrine/exocrine glands

abnormal thyroid follicular cell morphology ( J:158751 )

• thyroid follicular lesions

increased mammary gland tumor incidence ( J:158751 )

• mammary intraepithelial neoplasia in females

• females develop large palpable tumors with adenosquamous morphology and a prominent stromal component

• increased coincidence in females of mammary tumor and lymph node neoplasms

• a few males develop high grade mammary intraepithelial neoplasia

increased mammary adenoacanthoma incidence ( J:158751 )

• adenosquamous carcinoma

increased adrenal gland tumor incidence ( J:158751 )

• 70.7% of 9 month old mice develop proliferative lesions of the adrenal gland

increased prostate gland tumor incidence ( J:158751 )

♂ • 86.4% of 9 month old mice develop proliferative lesions of the prostate

increased T cell derived lymphoma incidence ( J:158751 )

• 59.5% of 9 month old mice develop proliferative lesions of the thymus

increased thyroid tumor incidence ( J:158751 )

• 81.6% of 9 month old mice develop proliferative lesions of the thyroid

reproductive system

increased prostate gland tumor incidence ( J:158751 )

♂ • 86.4% of 9 month old mice develop proliferative lesions of the prostate

endometrium hyperplasia ( J:158751 )

♀ • proliferative lesions of the endometrium, simple hyperplasia and atypical hyperplasia

integument

increased mammary gland tumor incidence ( J:158751 )

• mammary intraepithelial neoplasia in females

• females develop large palpable tumors with adenosquamous morphology and a prominent stromal component

• increased coincidence in females of mammary tumor and lymph node neoplasms

• a few males develop high grade mammary intraepithelial neoplasia

increased mammary adenoacanthoma incidence ( J:158751 )

• adenosquamous carcinoma

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Cowden syndrome		DOID:6457	OMIM:PS158350	J:158751