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Ptentm2.1Gle
Targeted Allele Detail
Summary
Symbol: Ptentm2.1Gle
Name: phosphatase and tensin homolog; targeted mutation 2.1, Gustavo Leone
MGI ID: MGI:4442331
Synonyms: PtenG129E
Gene: Pten  Location: Chr19:32734977-32803560 bp, + strand  Genetic Position: Chr19, 28.14 cM
Alliance: Ptentm2.1Gle page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:158751
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe codon GGA for Glycine 129 within exon 5, was mutated to GAA for Glutamate. In addition a floxed neo cassette was introduced within intron 4. The selection cassette was removed by cre mediated recombination. (J:158751)
Generation, targeting, and verification of point mutations of Pten alleles.
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 8 assay results
In Structures Affected by this Mutation: 4 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Ptentm2.1Gle
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pten Mutation:  81 strains or lines available
References
Original:  J:158751 Wang H, et al., Allele-specific tumor spectrum in Pten knockin mice. Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):5142-7
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory