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Phenotypes Associated with This Genotype
Genotype
MGI:5432232
Allelic
Composition		 Amhr2tm3(cre)Bhr/Amhr2+
Ctnnb1tm1Mmt/Ctnnb1+
Ptentm1Hwu/Ptentm1Hwu
Genetic
Background		 involves: 129S4/SvJae * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amhr2tm3(cre)Bhr mutation (1 available); any Amhr2 mutation (27 available)
Ctnnb1tm1Mmt mutation (0 available); any Ctnnb1 mutation (49 available)
Ptentm1Hwu mutation (16 available); any Pten mutation (81 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased granulosa cell tumor incidence ( J:186144 )
• female mutants develop granulosa cell tumors by 3 weeks of age
increased testis tumor incidence ( J:186144 )
• male mutants develop testicular granulosa cell tumors by 5 weeks of age

endocrine/exocrine glands
increased granulosa cell tumor incidence ( J:186144 )
• female mutants develop granulosa cell tumors by 3 weeks of age
increased testis tumor incidence ( J:186144 )
• male mutants develop testicular granulosa cell tumors by 5 weeks of age

reproductive system
increased granulosa cell tumor incidence ( J:186144 )
• female mutants develop granulosa cell tumors by 3 weeks of age
increased testis tumor incidence ( J:186144 )
• male mutants develop testicular granulosa cell tumors by 5 weeks of age

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory