About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5432232
Allelic
Composition		 Amhr2tm3(cre)Bhr/Amhr2+
Ctnnb1tm1Mmt/Ctnnb1+
Ptentm1Hwu/Ptentm1Hwu
Genetic
Background		 involves: 129S4/SvJae * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amhr2tm3(cre)Bhr mutation (1 available); any Amhr2 mutation (24 available)
Ctnnb1tm1Mmt mutation (0 available); any Ctnnb1 mutation (51 available)
Ptentm1Hwu mutation (17 available); any Pten mutation (86 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased granulosa cell tumor incidence ( J:186144 )
• female mutants develop granulosa cell tumors by 3 weeks of age
increased testis tumor incidence ( J:186144 )
• male mutants develop testicular granulosa cell tumors by 5 weeks of age

endocrine/exocrine glands
increased granulosa cell tumor incidence ( J:186144 )
• female mutants develop granulosa cell tumors by 3 weeks of age
increased testis tumor incidence ( J:186144 )
• male mutants develop testicular granulosa cell tumors by 5 weeks of age

reproductive system
increased granulosa cell tumor incidence ( J:186144 )
• female mutants develop granulosa cell tumors by 3 weeks of age
increased testis tumor incidence ( J:186144 )
• male mutants develop testicular granulosa cell tumors by 5 weeks of age

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/07/2025
MGI 6.24 		The Jackson Laboratory