Tg(Pbsn-TAg)15Tvd
Transgene Detail

Summary

• Symbol: Tg(Pbsn-TAg)15Tvd
• Name: transgene insertion 15, Terry Van Dyke
• MGI ID: MGI:3794201
• Synonyms: PB-TagAPT121, TgAPT121
• Transgene: Tg(Pbsn-TAg)15Tvd Location: unknown
• Alliance: Tg(Pbsn-TAg)15Tvd page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The 458pb ARR2PB promoter which is regulated by androgens and is activated during puberty was used to drive expression of the truncated SV40 large T antigen but not the small t antigen. The translation product contains the first 121 amino acids of SV40 T followed by 11 missense amino acids. (J:103408)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Pbsn-TAg)15Tvd

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:103408 Hill R, et al., Heterogeneous tumor evolution initiated by loss of pRb function in a preclinical prostate cancer model. Cancer Res. 2005 Nov 15;65(22):10243-54
• All: 7 reference(s)