Phenotypes Associated with This Genotype

Genotype
MGI:5897675

• Allelic Composition: Prkar1a^tm1.2Lsk/Prkar1a^tm1.2Lsk; Pten^tm1.1Mwst/Pten^tm1.1Mwst; Tg(TPO-cre)1Shk/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/NCr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:225245 )

• median survival age of 6 months

growth/size/body

weight loss ( J:225245 )

♂ • males exhibit lower body weight beginning at 1 month of age which becomes statistically significant at 5 months of age

endocrine/exocrine glands

enlarged thyroid gland ( J:225245 )

increased thyroid carcinoma incidence ( J:225245 )

• 100% of mice develop follicular thyroid carcinoma by 8 weeks of age, showing capsular and/or vascular invasion

• tumors show a molecular signature similar to human sporadic follicular thyroid cancer

increased activity of thyroid gland ( J:225245 )

• mice are hyperthyroid

adipose tissue

decreased subcutaneous adipose tissue amount ( J:225245 )

• reduction in subcutaneous adipose tissue

decreased abdominal adipose tissue amount ( J:225245 )

• reduction in visceral adipose tissue

homeostasis/metabolism

increased circulating thyroxine level ( J:225245 )

• free T4 levels are increased

integument

decreased subcutaneous adipose tissue amount ( J:225245 )

• reduction in subcutaneous adipose tissue

neoplasm

increased thyroid carcinoma incidence ( J:225245 )

• 100% of mice develop follicular thyroid carcinoma by 8 weeks of age, showing capsular and/or vascular invasion

• tumors show a molecular signature similar to human sporadic follicular thyroid cancer

increased metastatic potential ( J:225245 )

• metastatic follicular thyroid carcinoma is seen in the lungs of 27% of mice; metastases are well differentiated, maintain follicular structure with colloid, and stain for thyroglobulin

• tumors exhibit only mild increases in proliferation rate compared to those in single homozygous Prkar1a^tm1.2Lsk Tg(TPO-cre)1Shk/0 mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
follicular thyroid carcinoma		DOID:3962	OMIM:188470	J:241066