About   Help   FAQ
Targeted Allele Detail
Symbol: Ptentm2.1Ppp
Name: phosphatase and tensin homolog; targeted mutation 2.1, Pier Paolo Pandolfi
MGI ID: MGI:2679886
Synonyms: Ptenf, Ptenfl, PtenL, Ptenlox4-5, PtenloxP, Ptenlx
Gene: Pten  Location: Chr19:32734977-32803560 bp, + strand  Genetic Position: Chr19, 28.14 cM
Alliance: Ptentm2.1Ppp page
Germline Transmission:  Earliest citation of germline transmission: J:86212
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsExons 4 and 5 were left flanked by single loxP sites after the floxed neo cassette was removed from intron 3 of Ptentm2Ppp via in vivo cre mediated recombination.
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 104036 assay results
In Structures Affected by this Mutation: 6 anatomical structures
Tumor Data
List all tumor models in MMHCdb carrying Ptentm2.1Ppp
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pten Mutation:  77 strains or lines available

Phenotypic Similarity to Human Syndrome: Follicular Thyroid Carcinoma J:236513 (DOID:3962) in double Kras and Pten conditional (Tg(Tpo-cre)1Shk) mutants.

Phenotypic Similarity to Human Syndrome: Anaplastic Thyroid Cancer J:209788 in double Trp53 and Pten homozygous conditional (Tg(TPO-cre)1Shk) mice.

Original:  J:86212 Trotman LC, et al., Pten Dose Dictates Cancer Progression in the Prostate. PLoS Biol. 2003 Dec;1(3):385-96
All:  168 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
MGI 6.22
The Jackson Laboratory