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Phenotypes Associated with This Genotype
Genotype
MGI:2179025
Allelic
Composition		 Ptentm1Ppp/Pten+
Genetic
Background		 involves: 129S1/Sv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Ppp mutation (0 available); any Pten mutation (86 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased malignant tumor incidence ( J:49532 )
• increased incidence of malignant tumors of various histological origins; age of incidence beginning at 6 months

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Cowden syndrome DOID:6457 OMIM:PS158350
 J:49532
Cowden syndrome 1 DOID:0050657 OMIM:158350
 J:49532

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory