Phenotypes Associated with This Genotype

Genotype
MGI:5431978

• Allelic Composition: Pten^tm1Rdp/Pten^tm1Rdp; Tert^tm3Rdp/Tert^tm3Rdp; Trp53^tm1Brn/Trp53^tm1Brn; Tg(Pbsn-cre)4Prb/0
• Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased tumor-free survival time ( J:186105 )

• develop bulky lethal tumors by age 24 weeks of age

endocrine/exocrine glands

increased prostate gland adenocarcinoma incidence ( J:186105 )

♂ • at generations 3 and 4 (G3/4), all develop invasive prostate adenocarcinomas by 24 weeks of age

increased prostate intraepithelial neoplasia incidence ( J:186105 )

♂ • at G3/4, high-grade prostate intraepithelial neoplasia (HPIN) in all mice by 9 weeks of age

neoplasm

increased prostate gland adenocarcinoma incidence ( J:186105 )

♂ • at generations 3 and 4 (G3/4), all develop invasive prostate adenocarcinomas by 24 weeks of age

increased prostate intraepithelial neoplasia incidence ( J:186105 )

♂ • at G3/4, high-grade prostate intraepithelial neoplasia (HPIN) in all mice by 9 weeks of age

increased metastatic potential ( J:186105 )

• in some (5 of 20) G3/4 mice lumbar spine metastases are seen unlike in G0 mice

reproductive system

increased prostate gland adenocarcinoma incidence ( J:186105 )

♂ • at generations 3 and 4 (G3/4), all develop invasive prostate adenocarcinomas by 24 weeks of age

increased prostate intraepithelial neoplasia incidence ( J:186105 )

♂ • at G3/4, high-grade prostate intraepithelial neoplasia (HPIN) in all mice by 9 weeks of age

cellular

abnormal chromosome morphology ( J:186105 )

• increase in the number of chromosomal aberrations in tumor cells from G3/4 mice compared to G0 mice

increased telomere length ( J:186105 )

• increased length in prostate tumor cells compared to G3/4 mice homozygous for Tert^tm1Rdp, Pten^tm1Rdp and Trp53^tm1Brn and hemizygous for Tg(Pbsn-cre)4Prb

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:186105