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Targeted Allele Detail
Symbol: Cdkn2atm1Rdp
Name: cyclin dependent kinase inhibitor 2A; targeted mutation 1, Ronald DePinho
MGI ID: MGI:1857942
Synonyms: ARF-, Cdkn2a-, Cdkn2alox, ink4a-, INK4a-, Ink4a/arf-, Ink4a/Arf-, INK4a-Arf-, Ink4a/ArfKO, Ink4a-Arf-null, Inkdelta2/3 null, p16INK4a, p16INK4a-, p16-KO, p16p19null
Gene: Cdkn2a  Location: Chr4:89192710-89212856 bp, - strand  Genetic Position: Chr4, 42.15 cM, cytoband C3-C6
Alliance: Cdkn2atm1Rdp page
Degenerative phenotypes, including increased apoptosis in gastrointestinal crypts and germ cell depletion, in Terctm1Rdp/Terctm1Rdp and Cdkn2atm1Rdp/Cdkn2atm1Rdp Terctm1Rdp/Terctm1Rdp mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:53805
Parent Cell Line:  WW6 (ES Cell)
Strain of Origin:  STOCK 129/Sv and C57BL/6J and SJL
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons E2 and E3 were deleted and replaced by a neomycin cassette. Note that both the p16Ink4a and p19ARF alternative splice transcripts are mutated in this allele. (J:53805)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 3 assay results
In Structures Affected by this Mutation: 10 anatomical structures
Tumor Data
List all tumor models in MMHCdb carrying Cdkn2atm1Rdp
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 6 strains available      Cell Lines: 0 lines available
Carrying any Cdkn2a Mutation:  58 strains or lines available
Phenotypic Similarity to Human Syndrome in Orthologous Human Gene: human supratentorial ependymoma subgroup in homozygous mice (J:163931)
Original:  J:53805 Serrano M, et al., Role of the INK4a locus in tumor suppression and cell mortality. Cell. 1996 Apr 5;85(1):27-37
All:  319 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory