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Symbol
Name
ID
Pten
phosphatase and tensin homolog
MGI:109583
Phenotype annotations related to homeostasis/metabolism
*Aspects of the system are reported to show a normal phenotype.
!Indicates phenotype varies with strain background.
Darker colors indicate more annotations
Human Phenotypes
Decreased circulating antibody level
Hypoglycemia
Lymphedema
Hepatic steatosis
Disease(s) Associated with PTEN
Bannayan-Riley-Ruvalcaba syndrome
macrocephaly-autism syndrome

Mouse Phenotypes
homeostasis/metabolism phenotype
abnormal response to cardiac infarction
decreased myocardial infarct size
increased susceptibility to myocardial ischemic injury
increased myocardial infarct size
abnormal mitophagy
abnormal cellular cholesterol metabolism
increased insulin secretion
abnormal platelet activation
increased platelet aggregation
increased glutamic acid level
decreased blood oxygen capacity
decreased fasting circulating glucose level
decreased circulating glucose level
hypoglycemia
decreased circulating insulin level
decreased circulating insulin-like growth factor I level
decreased circulating leptin level
decreased circulating cholesterol level
decreased circulating free fatty acids level
increased circulating alanine transaminase level
increased circulating alkaline phosphatase level
increased circulating aspartate transaminase level
decreased bleeding time
cyanosis
increased dopamine level
increased energy expenditure
pulmonary edema
hypoxia
improved glucose tolerance
increased liver glycogen level
increased insulin sensitivity
increased follicle stimulating hormone level
increased luteinizing hormone level
decreased thyroid-stimulating hormone level
increased thyroid-stimulating hormone level
decreased thyroxine level
increased thyroxine level
increased liver cholesterol level
abnormal fatty acids level
increased saturated fatty acids level
increased liver triglyceride level
respiratory acidosis
abnormal cytokine level
increased basal metabolism
impaired lipolysis
decreased incidence of tumors by chemical induction
increased incidence of tumors by chemical induction
abnormal response to injury
abnormal response to CNS ischemic injury
decreased susceptibility to injury
Availability Mouse Genotype
Ptentm1.1Yxy/Ptentm1.1Yxy
Tg(Pten)1Srn/0
Ptentm1Hwu/Ptentm1Hwu
Tg(Gfap-cre)77.6Mvs/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Fabp4-cre)1Abel/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Pdx1-cre)89.1Dam/0  (conditional)
*
Ptentm1Hwu/Ptentm1Hwu
Lyz2tm1(cre)Ifo/Lyz2+  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Ins2-cre)25Mgn/0  (conditional)
*
Ptentm1Hwu/Ptentm1Hwu
Tg(Gdf9-icre)5092Coo/0  (conditional)
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Ptentm1Hwu/Ptentm1Hwu  (conditional)
Ptentm1Hwu/Ptentm1Hwu  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Slc6a3tm1.1(cre)Bkmn/Slc6a3+  (conditional)
Ptentm1Hwu/Ptentm1Hwu
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Ckmm-cre)5Khn/?  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Mx1-cre)1Cgn/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Nkx2-1-cre)2Sand/0  (conditional)
*!
Ptentm1Hwu/Ptentm1Hwu
Twist2tm1.1(cre)Dor/Twist2+  (conditional)
Ptentm2.1Ppp/Ptentm2.1Ppp
Tg(TPO-cre)1Shk/0  (conditional)
Ptentm2Mak/Ptentm2Mak
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+  (conditional)
Ptentm2Mak/Ptentm2Mak
Tg(SFTPC-rtTA)5Jaw/0
Tg(tetO-cre)1Jaw/0  (conditional)
Ptentm2Mak/Ptentm2Mak
Tg(Fabp1-cre)1Jig/0  (conditional)
Ptentm1Hwu/Pten+
Tg(Nkx2-1-cre)2Sand/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory