Symbol Name ID |
Pten
phosphatase and tensin homolog MGI:109583 |
* | Aspects of the system are reported to show a normal phenotype. |
! | Indicates phenotype varies with strain background. |
Darker colors indicate more annotations |
Human Phenotypes | Decreased circulating antibody level |
Hypoglycemia |
Lymphedema |
Hepatic steatosis |
Disease(s) Associated with PTEN | ||||
Bannayan-Riley-Ruvalcaba syndrome | ||||
macrocephaly-autism syndrome |
Mouse Phenotypes | homeostasis/metabolism phenotype |
abnormal response to cardiac infarction |
decreased myocardial infarct size |
increased susceptibility to myocardial ischemic injury |
increased myocardial infarct size |
abnormal mitophagy |
abnormal cellular cholesterol metabolism |
increased insulin secretion |
abnormal platelet activation |
increased platelet aggregation |
increased glutamic acid level |
decreased blood oxygen capacity |
decreased fasting circulating glucose level |
decreased circulating glucose level |
hypoglycemia |
decreased circulating insulin level |
decreased circulating insulin-like growth factor I level |
decreased circulating leptin level |
decreased circulating cholesterol level |
decreased circulating free fatty acids level |
increased circulating alanine transaminase level |
increased circulating alkaline phosphatase level |
increased circulating aspartate transaminase level |
decreased bleeding time |
cyanosis |
increased dopamine level |
increased energy expenditure |
pulmonary edema |
hypoxia |
improved glucose tolerance |
increased liver glycogen level |
increased insulin sensitivity |
increased follicle stimulating hormone level |
increased luteinizing hormone level |
decreased thyroid-stimulating hormone level |
increased thyroid-stimulating hormone level |
decreased thyroxine level |
increased thyroxine level |
increased liver cholesterol level |
abnormal fatty acids level |
increased saturated fatty acids level |
increased liver triglyceride level |
respiratory acidosis |
abnormal cytokine level |
increased basal metabolism |
impaired lipolysis |
decreased incidence of tumors by chemical induction |
increased incidence of tumors by chemical induction |
abnormal response to injury |
abnormal response to CNS ischemic injury |
decreased susceptibility to injury |
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Availability | Mouse Genotype | |||||||||||||||||||||||||||||||||||||||||||||||||||
Ptentm1.1Yxy/Ptentm1.1Yxy | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Tg(Pten)1Srn/0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Ptentm1Hwu/Ptentm1Hwu Tg(Gfap-cre)77.6Mvs/0 (conditional) |
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Ptentm1Hwu/Ptentm1Hwu Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ (conditional) |
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Ptentm1Hwu/Ptentm1Hwu Tg(Fabp4-cre)1Abel/0 (conditional) |
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Ptentm1Hwu/Ptentm1Hwu Tg(Pdx1-cre)89.1Dam/0 (conditional) |
* | |||||||||||||||||||||||||||||||||||||||||||||||||||
Ptentm1Hwu/Ptentm1Hwu Lyz2tm1(cre)Ifo/Lyz2+ (conditional) |
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Ptentm1Hwu/Ptentm1Hwu Tg(Ins2-cre)25Mgn/0 (conditional) |
* | |||||||||||||||||||||||||||||||||||||||||||||||||||
Ptentm1Hwu/Ptentm1Hwu Tg(Gdf9-icre)5092Coo/0 (conditional) |
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Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+ Ptentm1Hwu/Ptentm1Hwu (conditional) |
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Ptentm1Hwu/Ptentm1Hwu (conditional) | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Ptentm1Hwu/Ptentm1Hwu Slc6a3tm1.1(cre)Bkmn/Slc6a3+ (conditional) |
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Ptentm1Hwu/Ptentm1Hwu A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+ (conditional) |
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Ptentm1Hwu/Ptentm1Hwu Tg(Ckmm-cre)5Khn/? (conditional) |
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Ptentm1Hwu/Ptentm1Hwu Tg(Mx1-cre)1Cgn/0 (conditional) |
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Ptentm1Hwu/Ptentm1Hwu Tg(Nkx2-1-cre)2Sand/0 (conditional) |
*! | |||||||||||||||||||||||||||||||||||||||||||||||||||
Ptentm1Hwu/Ptentm1Hwu Twist2tm1.1(cre)Dor/Twist2+ (conditional) |
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Ptentm2.1Ppp/Ptentm2.1Ppp Tg(TPO-cre)1Shk/0 (conditional) |
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Ptentm2Mak/Ptentm2Mak Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ (conditional) |
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Ptentm2Mak/Ptentm2Mak Tg(SFTPC-rtTA)5Jaw/0 Tg(tetO-cre)1Jaw/0 (conditional) |
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Ptentm2Mak/Ptentm2Mak Tg(Fabp1-cre)1Jig/0 (conditional) |
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Ptentm1Hwu/Pten+ Tg(Nkx2-1-cre)2Sand/0 (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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