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Phenotypes Associated with This Genotype
Genotype
MGI:4838317
Allelic
Composition
Ptentm2.1Ppp/Ptentm2.1Ppp
Tg(TPO-cre)1Shk/0
Genetic
Background
129S1.Cg-Ptentm2.1Ppp Tg(TPO-cre)1Shk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm2.1Ppp mutation (0 available); any Pten mutation (83 available)
Tg(TPO-cre)1Shk mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• females have a reduced lifespan compared to males, with a mean survival age of 73 weeks compared to 83 weeks in males
• mutants start to show signs of illness starting after 1 year of age

endocrine/exocrine glands
• enlarged thyroid
• ovariectomization of females results in reduced proliferative index of thyroids to a similar level seen in males
• 52% of females develop thyroid follicular adenomas between 8-12 months of age compared to 12% of males
• 50% of the females and 35% of males over one year of age develop invasive and often metastatic thyroid follicular carcinomas

homeostasis/metabolism
• aging mice exhibit suppression of thyroid-stimulating hormone
• thyroxine levels are slightly, but significantly, increased in all mice with adenomas

neoplasm
• 52% of females develop thyroid follicular adenomas between 8-12 months of age compared to 12% of males
• 50% of the females and 35% of males over one year of age develop invasive and often metastatic thyroid follicular carcinomas

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
thyroid gland follicular carcinoma DOID:3962 OMIM:188470
J:165293


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/02/2024
MGI 6.13
The Jackson Laboratory