Phenotypes Associated with This Genotype

Genotype
MGI:3806986

• Allelic Composition: Pten^tm2Mak/Pten^tm2Mak; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

liver inflammation ( J:138099 )

• at 10 weeks of age

abnormal liver morphology ( J:138099 )

• by 40 weeks of age, livers contain Mallory bodies, ballooning hepatocytes and accumulation of lobular inflammatory cells

enlarged liver ( J:138099 )

• beginning at 10 weeks of age, mice exhibit enlargement of the liver that progressed further by 40 weeks of age

increased liver cholesterol level ( J:138099 )

• at 10 and 40 weeks of age

increased liver triglyceride level ( J:138099 )

• at 10 and 40 weeks of age

abnormal hepatocyte morphology ( J:138099 )

• at 10 weeks of age, the cytoplasm of hepatocytes contain lipid-filled micro- and macro-vesicular vacuoles unlike in wild-type mice

• at 40 weeks of age, micro- and macro-vesicular vacuoles coalesce to and displace the nucleus

Mallory bodies ( J:138099 )

• by 40 weeks of age, livers contain Mallory bodies

hepatic steatosis ( J:138099 )

• at 10 weeks of age

liver fibrosis ( J:138099 )

• at 40 weeks of age

pale liver ( J:138099 )

• beginning at 10 weeks of age, mice exhibit a pale liver that is white by 40 weeks of age

increased hepatocellular carcinoma incidence ( J:138099 )

• at 74 to 78 weeks of age, 83% of males and 50% of females exhibit hepatocellular carcinomas that develop within liver adenomas and contain fewer lipid droplets than the adenomas

• 2 of 6 mice exhibit metastasis of hepatocellular carcinomas to the lungs

increased liver adenoma incidence ( J:138099 )

• at 40 weeks of age, 66% of males and 30% of females exhibit liver adenomas that contain large lipid droplets

abnormal hepatocyte physiology ( J:220381 )

• the polyploid mononuclear hepatocyte population is enriched in the liver of 3 and 10 month old mutants

• highly polyploid hepatocytes are also present in hepatocellular tumors in the livers

increased hepatocyte proliferation ( J:138099 )

• at 10 weeks of age, hepatocyte proliferation is increased while apoptosis rates are normal

neoplasm

increased hepatocellular carcinoma incidence ( J:138099 )

• at 74 to 78 weeks of age, 83% of males and 50% of females exhibit hepatocellular carcinomas that develop within liver adenomas and contain fewer lipid droplets than the adenomas

• 2 of 6 mice exhibit metastasis of hepatocellular carcinomas to the lungs

increased liver adenoma incidence ( J:138099 )

• at 40 weeks of age, 66% of males and 30% of females exhibit liver adenomas that contain large lipid droplets

homeostasis/metabolism

increased circulating alanine transaminase level ( J:138099 )

• at 40 weeks of age

increased circulating alkaline phosphatase level ( J:138099 )

• at 40 weeks of age

increased liver cholesterol level ( J:138099 )

• at 10 and 40 weeks of age

increased liver triglyceride level ( J:138099 )

• at 10 and 40 weeks of age

immune system

liver inflammation ( J:138099 )

• at 10 weeks of age

cellular

increased hepatocyte proliferation ( J:138099 )

• at 10 weeks of age, hepatocyte proliferation is increased while apoptosis rates are normal

growth/size/body

enlarged liver ( J:138099 )

• beginning at 10 weeks of age, mice exhibit enlargement of the liver that progressed further by 40 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hepatocellular carcinoma		DOID:684	OMIM:114550	J:138099