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Phenotypes Associated with This Genotype
Genotype
MGI:5705321
Allelic
Composition
Krastm4Tyj/Kras+
Ptentm1Hwu/Ptentm1Hwu
Tg(Pbsn-cre)4Prb/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (76 available)
Ptentm1Hwu mutation (16 available); any Pten mutation (81 available)
Tg(Pbsn-cre)4Prb mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mice develop invasive carcinoma in both the dorsolateral and anterior lobes of the prostate as early as 4 weeks with poorly differentiated carcinoma by 10 weeks
• marker analysis indicates that prostatic epithelial cells undergo epithelial-to-mesenchymal transition and that tumors exhibit a human metastatic prostate cancer signature
• mice develop macrometastatic lesions in the lung and liver with 100% penetrance

mortality/aging
• early lethality, with mice dying between around 10 and 30 weeks of age

endocrine/exocrine glands
• prostates show an expansion of the leukemia stem cell (LSC)high subpopulation of stem/progenitor cells
• both the LSChigh (basal cell population) and LSClow (luminal cell population) subpopulations show enhanced sphere-forming in vitro
• mice develop invasive carcinoma in both the dorsolateral and anterior lobes of the prostate as early as 4 weeks with poorly differentiated carcinoma by 10 weeks
• marker analysis indicates that prostatic epithelial cells undergo epithelial-to-mesenchymal transition and that tumors exhibit a human metastatic prostate cancer signature

reproductive system
• prostates show an expansion of the leukemia stem cell (LSC)high subpopulation of stem/progenitor cells
• both the LSChigh (basal cell population) and LSClow (luminal cell population) subpopulations show enhanced sphere-forming in vitro
• mice develop invasive carcinoma in both the dorsolateral and anterior lobes of the prostate as early as 4 weeks with poorly differentiated carcinoma by 10 weeks
• marker analysis indicates that prostatic epithelial cells undergo epithelial-to-mesenchymal transition and that tumors exhibit a human metastatic prostate cancer signature


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/14/2024
MGI 6.23
The Jackson Laboratory