Phenotypes for Pgr Pten Trp53 MGI:3813634 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Pgr^tm2(cre)Lyd/Pgr⁺ Pten^tm1Hwu/Pten^tm1Hwu Trp53^tm1Brn/Trp53^tm1Brn
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pgr^tm2(cre)Lyd mutation (0 available); any Pgr mutation (73 available)
Pten^tm1Hwu mutation (16 available); any Pten mutation (81 available)
Trp53^tm1Brn mutation (18 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:139053 )

• impaired survival is seen beginning around 2 months of age

• death appears to result from excessive bleeding due to invasion of uterine blood vessels by tumor cells

reproductive system

increased endometrial carcinoma incidence ( J:139053 )

• hyperplasia progresses to carcinoma by 3 weeks of age

endometrium hyperplasia ( J:139053 )

• by P10, luminal and glandular epithelial hyperplasia are seen

enlarged uterus ( J:139053 )

• enlarged relative to conditional mutants that are wild type for Trp53

neoplasm

increased endometrial carcinoma incidence ( J:139053 )

• hyperplasia progresses to carcinoma by 3 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
endometrial cancer		DOID:1380	OMIM:608089	J:139053

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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