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Trp53 Gene Detail
Summary
  • Symbol
    Trp53
  • Name
    transformation related protein 53
  • Synonyms
    p44, p53
  • Feature Type
    protein coding gene
  • IDs
    MGI:98834
    NCBI Gene: 22059
Location & Maps
more
  • Sequence Map
    Chr11:69580359-69591873 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11515 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    TP53, tumor protein p53
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TP53, tumor protein p53
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BCC7, LFS1, P53, TRP53
  • Links
    NCBI Gene ID: 7157
    neXtProt AC: NX_P04637

  • Chr Location
    17p13.1; chr17:7668402-7687550 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    5 with Trp53 mouse models; 11 with human TP53 associations

Human Disease Mouse Models
       Breast Cancer   OMIM: 114480 View 11 models
Li-Fraumeni Syndrome 1; LFS1   OMIM: 151623 View 8 models
Osteogenic Sarcoma   OMIM: 259500 View 4 models
       Dyskeratosis Congenita, Autosomal Dominant 1; DKCA1   OMIM: 127550 View 1 model
Endometrial Cancer   OMIM: 608089 View 2 models
       Adrenocortical Carcinoma, Hereditary; ADCC   OMIM: 202300
Basal Cell Carcinoma, Susceptibility to, 7; BCC7   OMIM: 614740
Colorectal Cancer; CRC   OMIM: 114500
Glioma Susceptibility 1; GLM1   OMIM: 137800
Hepatocellular Carcinoma   OMIM: 114550
Nasopharyngeal Carcinoma   OMIM: 607107
Pancreatic Cancer   OMIM: 260350 View 12 models
Papilloma of Choroid Plexus; CPP   OMIM: 260500
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    13 with disease annotations
  • References
    85 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    271 phenotypes from 72 alleles in 75 genetic backgrounds
    455 phenotypes from multigenic genotypes
    6 images
    1931 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    322
  • Chemically induced (ENU)
    2
  • Chemically induced (other)
    1
  • Gene trapped
    221
  • Targeted
    84
  • Transgenic
    14
  • Genomic Mutations
    3 involving Trp53
  • Incidental Mutations
Mutations in this locus affect cell-cycle regulation and apoptosis. Null homozygotes show high, early-onset tumor incidence; some have persistent hyaloid vasculature and cataracts. Truncated or temperature-sensitive alleles cause early aging phenotypes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005982 VEGA Gene Model | MGI Sequence Detail 11515 C57BL/6J ±  kb
transcript OTTMUST00000013379 VEGA | MGI Sequence Detail 1772 Not Applicable  
polypeptide OTTMUSP00000006194 VEGA | MGI Sequence Detail 387 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    135 from dbSNP Build 137
  • PCR
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 172
    Genomic 15
    cDNA 136
    Primer pair 15
    Other 6

    Microarray probesets 9
Other
Accession IDs
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MGD-MRK-15247, MGI:3584375, MGI:3584378, MGI:3584379
References
more
  • Summaries
    All 2697
    Developmental Gene Expression 201
    Diseases 85
    Gene Ontology 131
    Phenotypes 1931
  • Earliest
    J:6969 Oren M, et al., Molecular cloning of a cDNA specific for the murine p53 cellular tumor antigen. Proc Natl Acad Sci U S A. 1983 Jan;80(1):56-9
  • Latest
    J:227866 Kuroda K, et al., Role of p53 in the progression from ochratoxin A-induced DNA damage to gene mutations in the kidneys of mice. Toxicol Sci. 2015 Mar;144(1):65-76

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory