About   Help   FAQ
Trp53
Gene Detail
Symbol

Name
ID
Trp53
transformation related protein 53
MGI:98834
Synonyms
p44, p53
Feature Type
protein coding gene
Genetic Map
Chromosome 11
42.83 cM, cytoband B2-C
Detailed Genetic Map ± 1 cM


Mapping data(41)
Sequence Map
Chr11:69580359-69591873 bp, + strand
From VEGA annotation of GRCm38

  11515 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:460  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TP53
Protein SuperFamily: tumor suppressor p53
Gene Tree: Trp53

Human
homologs
TP53, tumor protein p53
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 7157
neXtProt AC: NX_P04637

Human Synonyms: BCC7, LFS1, P53, TRP53

Human Chr (Location): 17p13.1; chr17:7668402-7687550 (-)  GRCh38.p2

Disease Associations: (11) Diseases Associated with Human TP53

Mutations,
alleles, and
phenotypes
All mutations/alleles(309) : Chemically induced (ENU)(2) Gene trapped(221) Targeted(82) Transgenic(4)
Genomic Mutations involving Trp53 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mutations in this locus affect cell-cycle regulation and apoptosis. Null homozygotes show high, early-onset tumor incidence; some have persistent hyaloid vasculature and cataracts. Truncated or temperature-sensitive alleles cause early aging phenotypes.
 
Human Diseases Modeled in Mice Using Trp53 (5)    Mutations Annotated to Human Diseases (13)    Phenotype Images(6)
Interactions
Trp53 interacts with 103 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (282 annotations)
Process apoptotic process, B cell lineage commitment, ...
Component chromatin, cytoplasm, ...
Function ATP binding, chaperone binding, ...
External Resources: FuncBase
Expression
Literature Summary: (190 records)
Data Summary: Results (506)    Tissues (277)    Images (70)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 57
RNA in situ 247
Northern blot 41
Western blot 37
RT-PCR 124
cDNA source data(127)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tp53 ; ZFIN tp53    NEW 
Molecular
reagents
All nucleic(170) Genomic(15) cDNA(136) Primer pair(13) Other(6)
Microarray probesets(9)
Other database
links
VEGA Gene Model OTTMUSG00000005982 (Evidence)
Ensembl Gene Model ENSMUSG00000059552 (Evidence)
Entrez Gene 22059 (Evidence)
UniGene 222
DFCI TC1575834, TC1586938, TC1591213, TC1715697
DoTS DT.101385652, DT.101385654, DT.101736545, DT.101736546, DT.492736
NIA Mouse Gene Index U012823, U272134
PDB 2GEQ, 2IOI, 2IOM, 2IOO, 3EXJ, 3EXL, 1HU8, 2P52
Consensus CDS Project CCDS36193.1, CCDS48826.1
International Mouse Phenotyping Consortium Status Trp53
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005982 VEGA Gene Model | MGI Sequence Detail 11515 C57BL/6J ±  kb
transcript OTTMUST00000013379 VEGA | MGI Sequence Detail 1772 Not Applicable 
polypeptide OTTMUSP00000006194 VEGA | MGI Sequence Detail 387 Not Applicable 

For the selected sequences
All sequences(96) RefSeq(6) UniProt(12)
Polymorphisms
All PCR and RFLP(10) : PCR(3) RFLP(7) SNPs within 2kb(135 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011615 p53, DNA-binding domain
InterPro IPR008967 p53-like transcription factor, DNA-binding
InterPro IPR012346 p53/RUNT-type transcription factor, DNA-binding domain
InterPro IPR010991 p53, tetramerisation domain
InterPro IPR013872 p53 transactivation domain
InterPro IPR002117 p53 tumour suppressor family
Protein Ontology PR:000003035 cellular tumor antigen p53
References
(Earliest) J:6969 Oren M, et al., Molecular cloning of a cDNA specific for the murine p53 cellular tumor antigen. Proc Natl Acad Sci U S A. 1983 Jan;80(1):56-9
(Latest) J:221201 Lahtela J, et al., The putative tumor suppressor gene EphA3 fails to demonstrate a crucial role in murine lung tumorigenesis or morphogenesis. Dis Model Mech. 2015 Apr;8(4):393-401
All references(2571)
Disease annotation references (25)
Other
accession IDs
MGD-MRK-15247, MGI:3584375, MGI:3584378, MGI:3584379

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory