Trp53
Gene Detail

Symbol Name ID

Trp53 transformation related protein 53 MGI:98834

Synonyms

p44, p53

Feature Type

protein coding gene

Genetic Map

Chromosome 11

42.83 cM, cytoband B2-C
Detailed Genetic Map ± 1 cM


Mapping data(41)

Sequence Map

Chr11:69580359-69591873 bp, + strand From VEGA annotation of GRCm38   11515 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cat, domestic; cattle; chimpanzee; dog, domestic; gorilla; hamster, Chinese; hamster, golden; pig, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Trp53 ± 2 cM)

Protein SuperFamily: tumor suppressor p53
Gene Tree: Trp53

Human ortholog

TP53 tumor protein p53 NCBI Gene ID 7157
Human Synonyms: BCC7, LFS1, P53, TRP53
Human Chr17:7571720-7590863 bp, - strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human TP53 (11)

Alleles and phenotypes

All alleles(293) : Targeted(70) Gene trapped(221) Chemically induced(2)
 

Mutations in this locus affect cell-cycle regulation and apoptosis. Null homozygotes show high, early-onset tumor incidence; some have persistent hyaloid vasculature and cataracts. Truncated or temperature-sensitive alleles cause early aging phenotypes.

 
Human Diseases Modeled Using Mouse Trp53 (18)    Alleles Annotated to Human Diseases(10)    Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (233 annotations)

Process	apoptotic process, B cell lineage commitment, ...
Component	chromatin, cytoplasm, ...
Function	ATP binding, chaperone binding, ...

External Resources: FuncBase

Expression

Literature Summary: (146 records)
Data Summary: Results (511)    Tissues (267)    Images (60)
Theiler Stages: 1, 2, 3, 4, 5, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	50
RNA in situ	245
Northern blot	54
Western blot	37
RT-PCR	125

cDNA source data(128)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(168) Genomic(15) cDNA(137) Primer pair(11) Other(5)
Microarray probesets(9)

Other database links

VEGA Gene Model	OTTMUSG00000005982 (Evidence)
Ensembl Gene Model	ENSMUSG00000059552 (Evidence)
Entrez Gene	22059 (Evidence)
UniGene	222
DFCI	TC1575834, TC1586938, TC1591213, TC1715697
DoTS	DT.101385652, DT.101385654, DT.101736545, DT.101736546, DT.492736
NIA Mouse Gene Index	U012823, U272134
PDB	1HU8, 2GEQ, 2IOI, 2IOM, 2IOO, 2P52, 3EXJ, 3EXL
Consensus CDS Project	CCDS36193.1, CCDS48826.1
International Mouse Knockout Project Status	Trp53

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005982	VEGA Gene Model | MGI Sequence Detail	11515	C57BL/6J
transcript	OTTMUST00000013379	VEGA | MGI Sequence Detail	1772	Not Applicable
polypeptide	OTTMUSP00000006194	VEGA | MGI Sequence Detail	387	Not Applicable

All sequences(91) RefSeq(4) UniProt(11)

Polymorphisms

All PCR and RFLP(10) : PCR(3) RFLP(7) SNPs(75 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011615	p53, DNA-binding domain
InterPro	IPR008967	p53-like transcription factor, DNA-binding
InterPro	IPR012346	p53/RUNT-type transcription factor, DNA-binding domain
InterPro	IPR010991	p53, tetramerisation domain
InterPro	IPR013872	p53 transactivation domain
InterPro	IPR002117	p53 tumour suppressor family
Protein Ontology	PR:000003035	cellular tumor antigen p53

References

(Earliest) J:6969 Oren M, et al., Molecular cloning of a cDNA specific for the murine p53 cellular tumor antigen. Proc Natl Acad Sci U S A. 1983 Jan;80(1):56-9
(Latest) J:194107 Lee JH, et al., DNA damage-specific control of cell death by cryptochrome in p53-mutant ras-transformed cells. Cancer Res. 2013 Jan 15;73(2):785-91
All references(2140)

Other accession IDs

MGD-MRK-15247, MGI:3584375, MGI:3584378, MGI:3584379