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Trp53 Gene Detail
Summary
  • Symbol
    Trp53
  • Name
    transformation related protein 53
  • Synonyms
    p44, p53
  • Feature Type
    protein coding gene
  • IDs
    MGI:98834
    NCBI Gene: 22059
  • Gene Overview
    MyGene.info: TP53
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:69580359-69591873 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11515 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 42.83 cM, cytoband B2-C
  • Mapping Data
    42 experiments
Homology
more
  • Human Ortholog
    TP53, tumor protein p53
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TP53, tumor protein p53
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BCC7, LFS1, P53, TRP53
  • Links
    NCBI Gene ID: 7157
    neXtProt AC: NX_P04637
    UniProt: P04637

  • Chr Location
    17p13.1; chr17:7668402-7687550 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    8 with Trp53 mouse models; 10 with human TP53 associations

Human Disease Mouse Models
      
IDs
View 14 models
IDs
View 8 models
IDs
View 8 models
      
IDs
View 1 model
IDs
View 2 models
IDs
View 1 model
IDs
View 2 models
IDs
View 2 models
      
IDs
IDs
View 1 model
IDs
IDs
IDs
IDs
IDs
View 12 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    17 with disease annotations
  • References
    87 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    298 phenotypes from 76 alleles in 79 genetic backgrounds
    494 phenotypes from multigenic genotypes
    13 images
    2285 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this locus affect cell-cycle regulation and apoptosis. Null homozygotes show high, early-onset tumor incidence; some have persistent hyaloid vasculature and cataracts. Truncated or temperature-sensitive alleles cause early aging phenotypes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000005982 VEGA Gene Model | MGI Sequence Detail 11515 C57BL/6J ±  kb
    transcript OTTMUST00000013379 VEGA | MGI Sequence Detail 1772 Not Applicable  
    polypeptide OTTMUSP00000006194 VEGA | MGI Sequence Detail 387 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      134 from dbSNP Build 142
    • PCR
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 172
      Genomic 15
      cDNA 136
      Primer pair 15
      Other 6

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-15247, MGI:3584375, MGI:3584378, MGI:3584379
    References
    more
    • Summaries
      All 3420
      Developmental Gene Expression 234
      Diseases 87
      Gene Ontology 145
      Phenotypes 2285
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:261384 Awasthi S, et al., Rlip depletion prevents spontaneous neoplasia in TP53 null mice. Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):3918-3923

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory