Trp53
Gene Detail

Symbol Name ID

Trp53 transformation related protein 53 MGI:98834

Synonyms

p44, p53

Feature Type

protein coding gene

Genetic Map

Chromosome 11

42.83 cM, cytoband B2-C
Detailed Genetic Map ± 1 cM


Mapping data(41)

Sequence Map

Chr11:69580359-69591873 bp, + strand From VEGA annotation of GRCm38   11515 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:460  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 zebrafish

Protein SuperFamily: tumor suppressor p53
Gene Tree: Trp53

Human homologs

Human Homolog		TP53, tumor protein p53
NCBI Gene ID		7157
neXtProt AC		NX_P04637
Human Synonyms		BCC7, LFS1, P53, TRP53
Human Chr (Location)		17p13.1; chr17:7571720-7590868 (-)  GRCh37.p10
Disease Associations		(11) Diseases Associated with Human TP53

Alleles and phenotypes

All alleles(294) : Targeted(71) Gene trapped(221) Chemically induced(2)
 

Mutations in this locus affect cell-cycle regulation and apoptosis. Null homozygotes show high, early-onset tumor incidence; some have persistent hyaloid vasculature and cataracts. Truncated or temperature-sensitive alleles cause early aging phenotypes.

 
Human Diseases Modeled Using Mouse Trp53 (14)    Alleles Annotated to Human Diseases(10)    Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (235 annotations)

Process	apoptotic process, B cell lineage commitment, ...
Component	chromatin, cytoplasm, ...
Function	ATP binding, chaperone binding, ...

External Resources: FuncBase

Expression

Literature Summary: (149 records)
Data Summary: Results (513)    Tissues (267)    Images (60)
Theiler Stages: 1, 2, 3, 4, 5, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	52
RNA in situ	245
Northern blot	54
Western blot	37
RT-PCR	125

cDNA source data(128)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(168) Genomic(15) cDNA(137) Primer pair(11) Other(5)
Microarray probesets(9)

Other database links

VEGA Gene Model	OTTMUSG00000005982 (Evidence)
Ensembl Gene Model	ENSMUSG00000059552 (Evidence)
Entrez Gene	22059 (Evidence)
UniGene	222
DFCI	TC1575834, TC1586938, TC1591213, TC1715697
DoTS	DT.101385652, DT.101385654, DT.101736545, DT.101736546, DT.492736
NIA Mouse Gene Index	U012823, U272134
PDB	2GEQ, 2IOI, 2IOM, 2IOO, 3EXJ, 3EXL, 1HU8, 2P52
Consensus CDS Project	CCDS36193.1, CCDS48826.1
International Mouse Knockout Project Status	Trp53

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005982	VEGA Gene Model | MGI Sequence Detail	11515	C57BL/6J
transcript	OTTMUST00000013379	VEGA | MGI Sequence Detail	1772	Not Applicable
polypeptide	OTTMUSP00000006194	VEGA | MGI Sequence Detail	387	Not Applicable

All sequences(91) RefSeq(4) UniProt(11)

Polymorphisms

All PCR and RFLP(10) : PCR(3) RFLP(7) SNPs(75 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011615	p53, DNA-binding domain
InterPro	IPR008967	p53-like transcription factor, DNA-binding
InterPro	IPR012346	p53/RUNT-type transcription factor, DNA-binding domain
InterPro	IPR010991	p53, tetramerisation domain
InterPro	IPR013872	p53 transactivation domain
InterPro	IPR002117	p53 tumour suppressor family
Protein Ontology	PR:000003035	cellular tumor antigen p53

References

(Earliest) J:6969 Oren M, et al., Molecular cloning of a cDNA specific for the murine p53 cellular tumor antigen. Proc Natl Acad Sci U S A. 1983 Jan;80(1):56-9
(Latest) J:194540 Gostissa M, et al., Conditional inactivation of p53 in mature B cells promotes generation of nongerminal center-derived B-cell lymphomas. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2934-9
All references(2162)

Other accession IDs

MGD-MRK-15247, MGI:3584375, MGI:3584378, MGI:3584379