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Nf1tm1Fcr
Targeted Allele Detail
Summary
Symbol: Nf1tm1Fcr
Name: neurofibromin 1; targeted mutation 1, Fredrick Cancer Research and Development Center
MGI ID: MGI:1857444
Synonyms: Nf1-, Nf1Fcr, Nf1mut
Gene: Nf1  Location: Chr11:79230519-79472438 bp, + strand  Genetic Position: Chr11, 46.74 cM, cytoband B4-5
Alliance: Nf1tm1Fcr page
Nf1tm1Fcr/Nf1+ Tg(GFAP-cre)#Gtm/0 mice develop prechiasmatic optic nerve and chiasmal gliomas

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:18048
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsInsertion of a neomycin cassette in the opposite transcriptional orientation into exon 31 of the Nf1 gene. Exon 31 was chosen as the mutation site because several point mutations exist at this site in human NF1 patients. This allele is a null allele; no RNA or protein is made from this mutated allele. (J:18048)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 6 assay results
1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 29 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Nf1tm1Fcr
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Nf1 Mutation:  158 strains or lines available
References
Original:  J:18048 Brannan CI, et al., Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues [published erratum appears in Genes Dev 1994 Nov 15;8(22):2792]. Genes Dev. 1994 May 1;8(9):1019-29
All:  89 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
07/02/2024
MGI 6.13
The Jackson Laboratory