Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 8.3.0)

Enables MDM2/MDM4 family protein binding activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including intrinsic apoptotic signaling pathway; positive regulation of programmed cell death; and regulation of transcription by RNA polymerase II. Located in mitochondrion and nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Used to study several diseases, including lung cancer (multiple); non-Hodgkin lymphoma (multiple); pancreatic carcinoma (multiple); reproductive organ cancer (multiple); and sarcoma (multiple). Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome (multiple); carcinoma (multiple); hematologic cancer (multiple); open-angle glaucoma (multiple); and pancreatic cancer (multiple). Orthologous to human TP53 (tumor protein p53).

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Gene Ontology Evidence Code Abbreviations:

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