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Targeted Allele Detail
Symbol: Trp53tm1Elee
Name: transformation related protein 53; targeted mutation 1, Eva YHP Lee
MGI ID: MGI:3043426
Synonyms: p53f5&6, p53flox, p53fp, p53koflox
Gene: Trp53  Location: Chr11:69471185-69482699 bp, + strand  Genetic Position: Chr11, 42.83 cM, cytoband B2-C
Alliance: Trp53tm1Elee page
Germline Transmission:  Earliest citation of germline transmission: J:90247
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsExons 5 and 6 were flanked by single loxP sites in introns 4 and 6. Recombination of these loxP sites will result in the deletion of codons 123 through 221, which encode part of the DNA-binding domain. (J:90247)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 3 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Trp53tm1Elee
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trp53 Mutation:  232 strains or lines available
Original:  J:90247 Lin SC, et al., Somatic mutation of p53 leads to estrogen receptor alpha-positive and -negative mouse mammary tumors with high frequency of metastasis. Cancer Res. 2004 May 15;64(10):3525-32
All:  23 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.13
The Jackson Laboratory