Phenotypes Associated with This Genotype

Genotype
MGI:3584463

• Allelic Composition: Trp53^tm2.1Tyj/Trp53⁺
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:95316 )

• mean life span is 15.2 months

neoplasm

increased metastatic potential ( J:95316 )

• tumors metastisize more frequently than those in Trp53^tm1Tyj or Trp53^tm3.1Tyj heterozygotes

cellular

decreased cellular sensitivity to gamma-irradiation ( J:95316 )

• resistance to gamma-irradiation induced apoptosis is increased compared to Trp53^tm1Tyj heterozygotes

increased cell proliferation ( J:95316 )

• a larger fraction of MEFs are in S phase compared to Trp53^tm1Tyj hterozygotes; however DNA damage-induced G1 arrest is intact

skeleton

osteopetrosis ( J:95316 )

• diffuse osteopetrosis is frequently observed with osteosarcomas

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Li-Fraumeni syndrome		DOID:3012	OMIM:PS151623	J:95316