Rb1^tm3Tyj
Targeted Allele Detail

Summary

• Symbol: Rb1^tm3Tyj
• Name: RB transcriptional corepressor 1; targeted mutation 3, Tyler Jacks
• MGI ID: MGI:2450162
• Synonyms: cRb^lox, Rb1^2lox, Rb1^lox, Rb^c, Rb^f, Rb^flox, Rb^loxP
• Gene: Rb1 Location: Chr14:73430298-73563446 bp, - strand Genetic Position: Chr14, 38.73 cM, cytoband D3
• Alliance: Rb1^tm3Tyj page

Increase in ploidy in hepatocytes of tamoxifen-treated Rb1^tm3Tyj/Rb1^tm3Tyj Tg(tetO-MYC)36aBop/0 Tg(Cebpb-tTA)5Bjd/0 mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81643
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Single loxP sites flank exon 3. (J:81643)

Disease models

Expression

In Mice Carrying this Mutation:	159 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Rb1^tm3Tyj

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 10 strains available Cell Lines: 0 lines available
• Carrying any Rb1 Mutation: 106 strains or lines available

References

• Original: J:81643 MacPherson D, et al., Conditional mutation of Rb causes cell cycle defects without apoptosis in the central nervous system. Mol Cell Biol. 2003 Feb;23(3):1044-53
• All: 105 reference(s)