Tg(Pdx1-cre)6Tuv
Transgene Detail
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Symbol: |
Tg(Pdx1-cre)6Tuv |
Name: |
transgene insertion 6, David A Tuveson |
MGI ID: |
MGI:3032531 |
Synonyms: |
Pdx1-cre, PDX-1-Cre, Pdx1-CreTg, Pdx1-CreTuv, Tg(Ipf1-cre)1Tuv, Tg(Ipf1-cre)6Tuv |
Transgene: |
Tg(Pdx1-cre)6Tuv Location: unknown Genetic Position: Chr8, Syntenic
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Alliance: |
Tg(Pdx1-cre)6Tuv page
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Ctnnb1tm4Wbm/Ctnnb1tm4Wbm Tg(Pdx1-cre)6Tuv/? pancreata display extensive loss of exocrine tissue
Show the 2 phenotype image(s) involving this allele.
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Transgene Type: |
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Transgenic (Recombinase) |
Mutation: |
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Insertion
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Tg(Pdx1-cre)6Tuv expression driven by
1 gene
Transgene expression driven by:
Organism |
Driver Gene |
Note |
Not Specified |
Pdx1 |
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Mutation details: The transgenic construct is composed of a Cre recombinase coding sequence under the control of the Pdx1 promoter. Cre expression is thus directed to islet cells of the pancreas. Line 6 was inserted into chromosome 8 about 48 kb upstream of Zfp423 (chr8:90,531,639; NCBI37/mm9) with elements of human ACTB 3'UTR and polyA signal, and a 1.5 kb genomic duplication at the integration site.
(J:87973, J:240920)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Pdx1
(species not specified)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 3 strains available
Cell Lines: 0 lines available
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Original: |
J:87973 Hingorani SR, et al., Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell. 2003 Dec;4(6):437-50 |
All: |
428 reference(s) |
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