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Zfp423 Gene Detail
Summary
  • Symbol
    Zfp423
  • Name
    zinc finger protein 423
  • Synonyms
    ataxia1, Ebfaz, mKIAA0760, Roaz, Zfp104
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891217
    NCBI Gene: 94187
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:88388438-88686223 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 42.29 cM, cytoband C4
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    7826 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891217
 protein coding gene Chr8:88388438-88688665 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033914
 protein coding gene Chr8:88683903-88993571 (-)
A/J MGP_AJ_G0033897
 protein coding gene Chr8:85201576-85505080 (-)
AKR/J MGP_AKRJ_G0033823
 protein coding gene Chr8:87719537-88020258 (-)
BALB/cJ MGP_BALBcJ_G0033890
 protein coding gene Chr8:85375163-85670284 (-)
C3H/HeJ MGP_C3HHeJ_G0033600
 protein coding gene Chr8:88320296-88629096 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034410
 protein coding gene Chr8:92040020-92360462 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031352
 protein coding gene Chr8:79208767-79508019 (-)
CAST/EiJ MGP_CASTEiJ_G0032931
 protein coding gene Chr8:87735443-88051818 (-)
CBA/J MGP_CBAJ_G0033576
 protein coding gene Chr8:95173279-95490404 (-)
DBA/2J MGP_DBA2J_G0033729
 protein coding gene Chr8:84803641-85103079 (-)
FVB/NJ MGP_FVBNJ_G0033676
 protein coding gene Chr8:83757210-84050183 (-)
LP/J MGP_LPJ_G0033821
 protein coding gene Chr8:88809917-89116786 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033719
 protein coding gene Chr8:97668193-97981060 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034429
 protein coding gene Chr8:87716399-88022878 (-)
PWK/PhJ MGP_PWKPhJ_G0032634
 protein coding gene Chr8:84069216-84371740 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032470
 protein coding gene Chr8:86513119-86831834 (-)
WSB/EiJ MGP_WSBEiJ_G0033042
 protein coding gene Chr8:88153295-88465005 (-)



Homology
more
  • Human Ortholog
    ZNF423, zinc finger protein 423
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZNF423, zinc finger protein 423
  • Synonyms
    Ebfaz, hOAZ, JBTS19, NPHP14, OAZ, Roaz, Zfp104, ZFP423
  • Links
    NCBI Gene ID: 23090
    UniProt: Q2M1K9

  • Chr Location
    16q12.1; chr16:49487524-49859279 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Zfp423 mouse models; 1 with human ZNF423 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    57 phenotypes from 8 alleles in 9 genetic backgrounds
    1 phenotype from multigenic genotypes
    1 images
    66 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this gene lead to postnatal lethality, abnormal gait, ataxia, reduced body size, loss of the corpus callosum, reduction of the hippocampus, olfactory bulb defects, and variable malformation of the cerebellum, including vermis agenesis, due to reduced proliferation of neural precursors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1035
  • Tissues
    214
  • cDNA Data
    12
  • Literature Summary
    28
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000045333 Ensembl Gene Model | MGI Sequence Detail 297786 C57BL/6J ±  kb
    transcript ENSMUST00000109655 Ensembl | MGI Sequence Detail 4907 Not Applicable  
    polypeptide ENSMUSP00000105282 Ensembl | MGI Sequence Detail 1292 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 13
      Primer pair 3
      Other 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2671459, MGI:894654
    References
    more
    • Summaries
      All 123
      Developmental Gene Expression 28
      Diseases 1
      Gene Ontology 12
      Phenotypes 66
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
    • Latest
      J:368679 Shen X, et al., Evidence That Dmrta2 Acts through Repression of Pax6 in Cortical Patterning and Identification of a Mutation Impairing DNA Recognition Associated with Microcephaly in Human. eNeuro. 2025 Jun;12(6)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/30/2025
    MGI 6.24     		The Jackson Laboratory