myelodysplastic syndrome Disease Ontology Browser

Disease Ontology Browser

myelodysplastic syndrome (DOID:0050908)
Alliance: disease page
Alt IDs: OMIM:614286, MESH:D009190, UMLS_CUI:C2713368
Definition: A bone marrow cancer that is characterized by under production of white blood cells, red blood cells and platelets.

Term Browser
Genes (43)
Models (21)

Disease References using Mouse Models (30)

Mouse Models

Human Disease Modeled: myelodysplastic syndrome
Associated Mouse Gene: Asxl1

Allelic Composition	Genetic Background	Reference	Phenotypes
Asxl1tm1.1Mjxu/Asxl1tm1.1Mjxu	involves: 129 * C57BL/6	J:208085	View
Tg(Vav1-Asxl1*Y588X)#Fcy/0	C57BL/6-Tg(Vav1-Asxl1*Y588X)#Fcy	J:257690	View
Asxl1tm1.1Mjxu/Asxl1+	involves: 129 * C57BL/6	J:208085	View
Asxl1tm1.1Iaai/Asxl1tm1.1Iaai Tg(Mx1-cre)1Cgn/0	involves: 129S/SvEv * C57BL/6 * CBA	J:208092	View
Asxl1tm1.1Iaai/Asxl1tm1.1Iaai Tg(VAV1-cre)1Graf/0	involves: 129S/SvEv * C57BL/6	J:208092	View

Mouse Models

Human Disease Modeled: myelodysplastic syndrome
Associated Mouse Gene: Sf3b1

Allelic Composition	Genetic Background	Reference	Phenotypes
Sf3b1tm1Hko/Sf3b1+	Not Specified	J:324276	View
Sf3b1tm1.1Mdf/Sf3b1+ Tet2tm1.1Iaai/Tet2tm1.1Iaai Tg(Mx1-cre)1Cgn/?	involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA/J	J:234976	View

Mouse Models

Human Disease Modeled: myelodysplastic syndrome
Associated Mouse Gene: Srsf2

Allelic Composition	Genetic Background	Reference	Phenotypes
Srsf2tm1.1Oaw/Srsf2+ Tg(Mx1-cre)1Cgn/?	B6.Cg-Tg(Mx1-cre)1Cgn Srsf2^tm1.1Oaw	J:221404	View

Mouse Models

Human Disease Modeled: myelodysplastic syndrome
Associated Mouse Gene: Atg7

Allelic Composition	Genetic Background	Reference	Phenotypes
Atg7tm1Tchi/Atg7tm1Tchi Commd10Tg(Vav1-icre)A2Kio/Commd10+	involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj	J:176843	View

Mouse Models

Human Disease Modeled: myelodysplastic syndrome
Associated Mouse Gene: Bap1

Allelic Composition	Genetic Background	Reference	Phenotypes
Bap1tm1.1Geno/Bap1tm1.1Geno Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+	involves: C57BL/6 * C57BL/6NTac	J:187380	View

Mouse Models

Human Disease Modeled: myelodysplastic syndrome
Associated Mouse Gene: Crebbp

Allelic Composition	Genetic Background	Reference	Phenotypes
Crebbptm1Dli/Crebbp+	involves: 129S6/SvEvTac * C57BL/6	J:191503	View

Mouse Models

Human Disease Modeled: myelodysplastic syndrome
Associated Mouse Gene: Egr1

Allelic Composition	Genetic Background	Reference	Phenotypes
Egr1tm1Jmi/Egr1tm1Jmi	involves: 129 * C57BL/6	J:123870	View

Mouse Models

Human Disease Modeled: myelodysplastic syndrome
Associated Mouse Gene: Gata1

Allelic Composition	Genetic Background	Reference	Phenotypes
Gata1tm1Mym/Gata1+	involves: 129P2/OlaHsd	J:88685	View

Mouse Models

Human Disease Modeled: myelodysplastic syndrome
Associated Mouse Gene: Macroh2a1

Allelic Composition	Genetic Background	Reference	Phenotypes
Macroh2a1tm1.1Oxbo/Macroh2a1tm1.1Oxbo	B6.Cg-Macroh2a1^tm1.1Oxbo	J:293382	View

Mouse Models

Human Disease Modeled: myelodysplastic syndrome
Associated Mouse Gene: Mybl2

Allelic Composition	Genetic Background	Reference	Phenotypes
Mybl2tm1.1Jof/Mybl2+ Tg(Zp3-cre)3Mrt/0	involves: 129S2/SvPas * C57BL/6 * FVB/N	J:196804	View

Mouse Models

Human Disease Modeled: myelodysplastic syndrome
Associated Mouse Gene: Npm1

Allelic Composition	Genetic Background	Reference	Phenotypes
Npm1tm1Ppp/Npm1+	involves: 129S1/Sv * C57BL/6	J:101494	View

Mouse Models

Human Disease Modeled: myelodysplastic syndrome
Associated Mouse Gene: Polg

Allelic Composition	Genetic Background	Reference	Phenotypes
Polgtm1Prol/Polgtm1Prol	B6J.129S7-Polg^tm1Prol	J:154187	View

Mouse Models

Human Disease Modeled: myelodysplastic syndrome
Associated Mouse Gene: Samd9l

Allelic Composition	Genetic Background	Reference	Phenotypes
Samd9ltm1Homy/Samd9l+	involves: 129P2/OlaHsd	J:202604	View

Mouse Models

Human Disease Modeled: myelodysplastic syndrome

Allelic Composition	Genetic Background	Reference	Phenotypes
Sf3b1tm1.1Mdf/Sf3b1+ Tet2tm1.1Iaai/Tet2tm1.1Iaai Tg(Mx1-cre)1Cgn/?	involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA/J	J:234976	View

Mouse Models

Human Disease Modeled: myelodysplastic syndrome
Associated Mouse Transgene: Tg(CMV-SALL4_iB)#Chai

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(CMV-SALL4_iB)#Chai/?	Not Specified	J:115037	View

Mouse Models

Human Disease Modeled: myelodysplastic syndrome
Associated Mouse Transgene: Tg(Vav1-Asxl1*Y588X)#Fcy

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Vav1-Asxl1*Y588X)#Fcy/0	C57BL/6-Tg(Vav1-Asxl1*Y588X)#Fcy	J:257690	View

Mouse Models

Human Disease Modeled: myelodysplastic syndrome
Associated Mouse Transgene: Tg(Vav1-NUP98/HOXD13)C1Apla

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Vav1-NUP98/HOXD13)C1Apla/0	FVB/N-Tg(Vav1-NUP98/HOXD13)C1Apla	J:107446	View

Mouse Models

Human Disease Modeled: myelodysplastic syndrome
Associated Mouse Transgene: Tg(Vav1-NUP98/HOXD13)G2Apla

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Vav1-NUP98/HOXD13)G2Apla/0	C57BL/6-Tg(Vav1-NUP98/HOXD13)G2Apla	J:107446	View

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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