myelodysplastic syndrome Disease Ontology Browser

Disease Ontology Browser

myelodysplastic syndrome (DOID:0050908)
Alliance: disease page
Alt IDs: OMIM:614286, MESH:D009190, UMLS_CUI:C2713368
Definition: A bone marrow cancer that is characterized by under production of white blood cells, red blood cells and platelets.

Term Browser
Genes (43)
Models (21)

Disease References using Mouse Models (31)

Mouse Models

Human Disease Modeled: myelodysplastic syndrome
Associated Mouse Gene: Asxl1

Allelic Composition	Genetic Background	Reference	Phenotypes
\Asxl1tm1.1Mjxu/\Asxl1tm1.1Mjxu	involves: 129 * C57BL/6	J:208085	View
\Tg(Vav1-Asxl1*Y588X)#Fcy/0	C57BL/6-Tg(Vav1-Asxl1*Y588X)#Fcy	J:257690	View
\Asxl1tm1.1Mjxu/\Asxl1+	involves: 129 * C57BL/6	J:208085	View
\Asxl1tm1.1Iaai/\Asxl1tm1.1Iaai \Tg(Mx1-cre)1Cgn/0	involves: 129S/SvEv * C57BL/6 * CBA	J:208092	View
\Asxl1tm1.1Iaai/\Asxl1tm1.1Iaai \Tg(VAV1-cre)1Graf/0	involves: 129S/SvEv * C57BL/6	J:208092	View

Mouse Models

Human Disease Modeled: myelodysplastic syndrome
Associated Mouse Gene: Sf3b1

Allelic Composition	Genetic Background	Reference	Phenotypes
\Sf3b1tm1Hko/\Sf3b1+	Not Specified	J:324276	View
\Sf3b1tm1.1Mdf/\Sf3b1+ \Tet2tm1.1Iaai/\Tet2tm1.1Iaai \Tg(Mx1-cre)1Cgn/?	involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA/J	J:234976	View

Mouse Models

Human Disease Modeled: myelodysplastic syndrome
Associated Mouse Gene: Srsf2

Allelic Composition	Genetic Background	Reference	Phenotypes
\Srsf2tm1.1Oaw/\Srsf2+ \Tg(Mx1-cre)1Cgn/?	B6.Cg-Tg(Mx1-cre)1Cgn Srsf2^tm1.1Oaw	J:221404	View

Mouse Models

Human Disease Modeled: myelodysplastic syndrome
Associated Mouse Gene: Atg7

Allelic Composition	Genetic Background	Reference	Phenotypes
\Atg7tm1Tchi/\Atg7tm1Tchi \Commd10Tg(Vav1-icre)A2Kio/\Commd10+	involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj	J:176843	View

Mouse Models

Human Disease Modeled: myelodysplastic syndrome
Associated Mouse Gene: Bap1

Allelic Composition	Genetic Background	Reference	Phenotypes
\Bap1tm1.1Geno/\Bap1tm1.1Geno \Gt(ROSA)26Sortm9(cre/ESR1)Arte/\Gt(ROSA)26Sor+	involves: C57BL/6 * C57BL/6NTac	J:187380	View

Mouse Models

Human Disease Modeled: myelodysplastic syndrome
Associated Mouse Gene: Crebbp

Allelic Composition	Genetic Background	Reference	Phenotypes
\Crebbptm1Dli/\Crebbp+	involves: 129S6/SvEvTac * C57BL/6	J:191503	View

Mouse Models

Human Disease Modeled: myelodysplastic syndrome
Associated Mouse Gene: Egr1

Allelic Composition	Genetic Background	Reference	Phenotypes
\Egr1tm1Jmi/\Egr1tm1Jmi	involves: 129 * C57BL/6	J:123870	View

Mouse Models

Human Disease Modeled: myelodysplastic syndrome
Associated Mouse Gene: Gata1

Allelic Composition	Genetic Background	Reference	Phenotypes
\Gata1tm1Mym/\Gata1+	involves: 129P2/OlaHsd	J:88685	View

Mouse Models

Human Disease Modeled: myelodysplastic syndrome
Associated Mouse Gene: Macroh2a1

Allelic Composition	Genetic Background	Reference	Phenotypes
\Macroh2a1tm1.1Oxbo/\Macroh2a1tm1.1Oxbo	B6.Cg-Macroh2a1^tm1.1Oxbo	J:293382	View

Mouse Models

Human Disease Modeled: myelodysplastic syndrome
Associated Mouse Gene: Mybl2

Allelic Composition	Genetic Background	Reference	Phenotypes
\Mybl2tm1.1Jof/\Mybl2+ \Tg(Zp3-cre)3Mrt/0	involves: 129S2/SvPas * C57BL/6 * FVB/N	J:196804	View

Mouse Models

Human Disease Modeled: myelodysplastic syndrome
Associated Mouse Gene: Npm1

Allelic Composition	Genetic Background	Reference	Phenotypes
\Npm1tm1Ppp/\Npm1+	involves: 129S1/Sv * C57BL/6	J:101494	View

Mouse Models

Human Disease Modeled: myelodysplastic syndrome
Associated Mouse Gene: Polg

Allelic Composition	Genetic Background	Reference	Phenotypes
\Polgtm1Prol/\Polgtm1Prol	B6J.129S7-Polg^tm1Prol	J:154187	View

Mouse Models

Human Disease Modeled: myelodysplastic syndrome
Associated Mouse Gene: Samd9l

Allelic Composition	Genetic Background	Reference	Phenotypes
\Samd9ltm1Homy/\Samd9l+	involves: 129P2/OlaHsd	J:202604	View

Mouse Models

Human Disease Modeled: myelodysplastic syndrome

Allelic Composition	Genetic Background	Reference	Phenotypes
\Sf3b1tm1.1Mdf/\Sf3b1+ \Tet2tm1.1Iaai/\Tet2tm1.1Iaai \Tg(Mx1-cre)1Cgn/?	involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA/J	J:234976	View

Mouse Models

Human Disease Modeled: myelodysplastic syndrome
Associated Mouse Transgene: Tg(CMV-SALL4_iB)#Chai

Allelic Composition	Genetic Background	Reference	Phenotypes
\Tg(CMV-SALL4_iB)#Chai/?	Not Specified	J:115037	View

Mouse Models

Human Disease Modeled: myelodysplastic syndrome
Associated Mouse Transgene: Tg(Vav1-Asxl1*Y588X)#Fcy

Allelic Composition	Genetic Background	Reference	Phenotypes
\Tg(Vav1-Asxl1*Y588X)#Fcy/0	C57BL/6-Tg(Vav1-Asxl1*Y588X)#Fcy	J:257690	View

Mouse Models

Human Disease Modeled: myelodysplastic syndrome
Associated Mouse Transgene: Tg(Vav1-NUP98/HOXD13)C1Apla

Allelic Composition	Genetic Background	Reference	Phenotypes
\Tg(Vav1-NUP98/HOXD13)C1Apla/0	FVB/N-Tg(Vav1-NUP98/HOXD13)C1Apla	J:107446	View

Mouse Models

Human Disease Modeled: myelodysplastic syndrome
Associated Mouse Transgene: Tg(Vav1-NUP98/HOXD13)G2Apla

Allelic Composition	Genetic Background	Reference	Phenotypes
\Tg(Vav1-NUP98/HOXD13)G2Apla/0	C57BL/6-Tg(Vav1-NUP98/HOXD13)G2Apla	J:107446	View

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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