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Transgene Detail
Symbol: Tg(Vav1-NUP98/HOXD13)G2Apla
Name: transgene insertion G2, Peter Aplan
MGI ID: MGI:4357686
Synonyms: NHD13 tg
Transgene: Tg(Vav1-NUP98/HOXD13)G2Apla  Location: unknown  
Alliance: Tg(Vav1-NUP98/HOXD13)G2Apla page
Strain of Origin:  C57BL/6
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(Vav1-NUP98/HOXD13)G2Apla expresses 2 genes
Mutation detailsA transgenic construct containing cDNA of the amino-terminal region of the human nucleoporin 98kDa (NUP98) fused to the homeodomain of the human homeobox D13 (HOXD13) under the control of the 3' and 5' mouse vav 1 oncogene (Vav1) regulatory elements and SV40 polyadenylation site sequence was injected into fertilized C57BL/6 mouse eggs. Founder line G2 was subsequently established. The transgene is expressed specifically in hematopoietic tissues and is detected in thymus, spleen, and bone marrow and not in brain, liver, and kidney (by Northern blot analysis of total RNA). (J:107446)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:107446 Lin YW, et al., NUP98-HOXD13 transgenic mice develop a highly penetrant, severe myelodysplastic syndrome that progresses to acute leukemia. Blood. 2005 Jul 1;106(1):287-95
All:  24 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory