Tg(VAV1-cre)1Graf
Transgene Detail
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Symbol: |
Tg(VAV1-cre)1Graf |
Name: |
transgene insertion 1, Thomas Graf |
MGI ID: |
MGI:3765313 |
Synonyms: |
vav-Cre |
Transgene: |
Tg(VAV1-cre)1Graf Location: unknown
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Alliance: |
Tg(VAV1-cre)1Graf page
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Strain of Origin: |
Not Specified
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Transgene Type: |
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Transgenic (Recombinase) |
Mutation: |
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Insertion
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Tg(VAV1-cre)1Graf expression driven by
1 gene
Transgene expression driven by:
Organism |
Driver Gene |
Note |
Not Specified |
Vav1 |
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Mutation details: A bicistronic sequence coding for Cre recombinase and YFP linked by an IRES domain was placed downstream of human VAV1 promoter sequence and upstream of VAV1 enhancer sequence. The entire construct was flanked by two 250 bp core elements from chicken beta globulin insulator. Transgenic mice failed to express YFP but crossing with a Gt(ROSA)26Sortm1(EYFP)Cos reporter strained revealed that 70% of mice had cre expression restricted to hematopoietic cells, including hematopoietic stem cells. The remaining 30% had cre expression in a wider range of cells, possibly due to transient expression of the transgene in early blastomeres.
(J:127936)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Vav1
(species not specified)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:127936 Stadtfeld M, et al., Assessing the role of hematopoietic plasticity for endothelial and hepatocyte development by non-invasive lineage tracing. Development. 2005 Jan;132(1):203-13 |
All: |
107 reference(s) |
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