Tg(CMV-SALL4_iB)#Chai
Transgene Detail

Summary

• Symbol: Tg(CMV-SALL4_iB)#Chai
• Name: transgene insertion, Li Chai
• MGI ID: MGI:5558103
• Transgene: Tg(CMV-SALL4_iB)#Chai Location: unknown
• Alliance: Tg(CMV-SALL4_iB)#Chai page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(CMV-SALL4_iB)#Chai expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SALL4 (57167)

  Sall4

  (MGI:2139360)

  The gene expresses the B isoform.

• Mutation details: The CMV promoter drives the expression of a cDNA encoding the 617 amino acids of human SALL4, isoform B. The B isoform lacks the region corresponding to amino acids 385 to 820 (3' part of exon 2) of the full-length A isoform and contains 3 zinc finger domains. Six lines were established (464, 504, 506, 507, 509, and 510) however, the pound symbol (#) is used when line is not specified and/or lines are pooled. (J:115037)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:115037 Ma Y, et al., SALL4, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML in transgenic mice. Blood. 2006 Oct 15;108(8):2726-35
• All: 2 reference(s)