Analysis Tools
mortality/aging
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• more than half of females die within 7 months of birth
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• more than 50% of females die within 7 months of birth
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hematopoietic system
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• varying degrees of splenomegaly, with an accumulation of proerythroblasts and megakaryocytes
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• ectopic liver hematopoiesis
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• mutants with severe splenomegaly that die spontaneously exhibit a diminished number of megakaryocytes in the enlarged spleens, however mutants with moderate splenomegaly, exhibit massive accumulation of megakaryocytes in the spleen
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• massive accumulation of proerythroblasts in the spleen, resulting in almost no white pulp and only residual visible red pulp
• high numbers of proerythroblasts are seen in the peripheral blood of mice with severe anemia
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• only residual red pulp due to massive accumulation of proerythroblasts in the spleen
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• almost no white pulp due to massive accumulation of proerythroblasts in the spleen
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pale spleen
(
J:88685
)
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immune system
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• varying degrees of splenomegaly, with an accumulation of proerythroblasts and megakaryocytes
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• only residual red pulp due to massive accumulation of proerythroblasts in the spleen
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• almost no white pulp due to massive accumulation of proerythroblasts in the spleen
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pale spleen
(
J:88685
)
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growth/size/body
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• varying degrees of splenomegaly, with an accumulation of proerythroblasts and megakaryocytes
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| myelodysplastic syndrome | DOID:0050908 |
OMIM:614286 |
J:88685 | |
