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Crebbptm1Dli
Targeted Allele Detail
Summary
Symbol: Crebbptm1Dli
Name: CREB binding protein; targeted mutation 1, David Livingston
MGI ID: MGI:1926888
Synonyms: CBP-
Gene: Crebbp  Location: Chr16:3899198-4031864 bp, - strand  Genetic Position: Chr16, 2.4 cM
Alliance: Crebbptm1Dli page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:60630
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Replacement of two exons encoding the CH1 domain of the Crebbp gene with a neomycin cassette. (J:60630)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Tumor Data
List all tumor models in MMHCdb carrying Crebbptm1Dli
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Crebbp Mutation:  71 strains or lines available
References
Original:  J:60630 Kung AL, et al., Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP. Genes Dev. 2000 Feb 1;14(3):272-7
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/17/2023
MGI 6.22
The Jackson Laboratory