Brca1^tm1.1Jjon
Targeted Allele Detail

Summary

• Symbol: Brca1^tm1.1Jjon
• Name: breast cancer 1, early onset; targeted mutation 1.1, Jos Jonkers
• MGI ID: MGI:5307254
• Synonyms: Brca1^C61G
• Gene: Brca1 Location: Chr11:101379590-101442781 bp, - strand Genetic Position: Chr11, 65.18 cM, cytoband D
• Alliance: Brca1^tm1.1Jjon page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178595
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Humanized sequence, Hypomorph)
• Mutations: Insertion, Single point mutation
• Mutation details: A floxed neo cassette was inserted upstream of exon 5 and a T to G mutation, resulting in a cysteine to glycine substitution at amino acid position 61 (C61G) in a conserved RING domain, was introduced via homologous recombination. Cre mediated recombination removed the neo cassette. (J:178595)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Brca1 Mutation: 113 strains or lines available

References

• Original: J:178595 Drost R, et al., BRCA1 RING Function Is Essential for Tumor Suppression but Dispensable for Therapy Resistance. Cancer Cell. 2011 Dec 13;20(6):797-809
• All: 2 reference(s)