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Tg(KRT14-cre)8Brn
Transgene Detail
Summary
Symbol: Tg(KRT14-cre)8Brn
Name: transgene insertion 8, Anton Berns
MGI ID: MGI:2177243
Synonyms: K14cre, K14-Cre, Tg(K14-Cre)8Brn, Tg(KRT14-cre)1Brn
Transgene: Tg(KRT14-cre)8Brn  Location: unknown  
Alliance: Tg(KRT14-cre)8Brn page
Histological and Immunochemical examinaton of skin and teeth of Apctm2Rak/Apctm2Rak Tg(KRT14-cre)8Brn/0 mice at P12

Show the 10 phenotype image(s) involving this allele.

Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Tg(KRT14-cre)8Brn expression driven by 1 gene
 
Mutation detailsThis transgene expresses Cre recombinase under the control of a human keratin 14 promoter. This promoter is active in skin, salivary gland and mammary gland epithelium. Mammary gland epithelium recombination efficiency was estimated at a weak 5-30%. (J:73028)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: KRT14 (human)
Summary of all recombinase alleles driven by KRT14.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 4 RNA-Seq or microarray experiment(s)
Tumor Data
List all tumor models in MMHCdb carrying Tg(KRT14-cre)8Brn
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
References
Original:  J:73028 Jonkers J, et al., Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer. Nat Genet. 2001 Dec;29(4):418-25
All:  127 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
10/01/2024
MGI 6.24
The Jackson Laboratory